1615245-38-9

Basic information

• Product Name: (E)-3-(4-(2-(diethylamino)ethoxy)phenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one
• CAS NO: 1615245-38-9
• Molecular Weight: 421.536
• Mol File: 1615245-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-(4-(2-(diethylamino)ethoxy)phenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-(2-(diethylamino)ethoxy)phenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one(1615245-38-9)
• EPA Substance Registry System: (E)-3-(4-(2-(diethylamino)ethoxy)phenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one(1615245-38-9)

Safety Data

• Hazardous Substances Data: 1615245-38-9(Hazardous Substances Data)

Upstream product

• 24672-84-2 6-acetyl-5-hydroxy-2,2-dimethylchromene 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 56083-03-5 4-hydroxylonchocarpin 

Relevant articles and documents

Synthesis and biological evaluation of chalcones as potential antileishmanial agents

Antileishmanial activities of thirty-five synthetic chalcones have been examined. Among them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity (IC50 range from 1.70 to 8 μM) against extracellular promastigotes and intracellular amastigotes form of Leishmania donovani. Two promising compounds 22 and 37 were tested in vivo in L. donovani/hamster model. Chalcone 37 showed 83.32% parasite inhibition at a dose of 50 mg/kg for 10 days whereas, 75.89% parasite inhibition at 100 mg/kg dose for 5 days by intraperitoneal route at day 7 post-treatment.