56083-03-5

Basic information

• Product Name: IsobavachroMene
• Synonyms: IsobavachroMene;(2E)-1-(5-Hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one;4-Hydroxylonchocarpin
• CAS NO: 56083-03-5
• Molecular Formula: C₂₀H₁₈O₄
• Molecular Weight: 322.35452
• Mol File: 56083-03-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 203-204℃
• Boiling Point: 535.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• PKA: 7.25±0.40(Predicted)
• CAS DataBase Reference: IsobavachroMene(CAS DataBase Reference)
• NIST Chemistry Reference: IsobavachroMene(56083-03-5)
• EPA Substance Registry System: IsobavachroMene(56083-03-5)

Safety Data

• Hazardous Substances Data: 56083-03-5(Hazardous Substances Data)

Usage

General Description

IsobavachroMene is a natural chemical compound found in plants such as Psoralea corylifolia and Angelica dahurica. It belongs to the group of compounds known as coumarins, which have been studied for their potential therapeutic effects. IsobavachroMene has been investigated for its anti-inflammatory, anti-cancer, and antioxidant properties. It has also been shown to have potential in the treatment of various health conditions such as skin disorders, cardiovascular diseases, and neurodegenerative disorders. IsobavachroMene is being researched for its potential as a natural alternative for treating various diseases and may have potential in the development of new pharmaceutical drugs.

Upstream product

• 107-86-8 3,3-dimethyl acrylaldehyde 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 525-25-7 β-tubaic acid 
• 24672-84-2 6-acetyl-5-hydroxy-2,2-dimethylchromene 
• 885118-28-5 5-hydroxy-2,2-dimethyl-2H-chromene-6-carboxylic acid ethyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 
• 19825-40-2 2,4-Dihydroxy-3-C-prenylacetophenone 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 

Downstream Products

• 1615245-38-9 (E)-3-(4-(2-(diethylamino)ethoxy)phenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one 
• 1615245-39-0 (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)prop-2-en-1-one 
• 1615245-40-3 (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-(2-(piperidin-1-yl)ethoxy)phenyl)prop-2-en-1-one 
• 1615245-41-4 (E)-1-(5-(2-(diethylamino) ethoxy)-2, 2-dimethyl-2H-chromen-6-yl)-3-(4-(2-(diethylamino)ethoxy) phenyl)prop-2-en-1-one 
• 1615245-42-5 (E)-1-(2,2-dimethyl-5-(2-(pyrrolidin-1-yl)ethoxy)-2H-chromen-6-yl)-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)prop-2-en-1-one 
• 1416512-06-5 1-[2,2-dimethyl-5-(2-piperidin-1-yl-ethoxy)-2H-chromen-6-yl]-3-[4-(2-piperidin-1-ylethoxy)-phenyl]-prop-2-en-1-one 
• 78316-30-0 4'-hydroxy-2,2-dimethylpyrano<5,6:8,7>flavanone 

Relevant articles and documents

Synthesis and biological evaluation of chalcones as potential antileishmanial agents

Antileishmanial activities of thirty-five synthetic chalcones have been examined. Among them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity (IC50 range from 1.70 to 8 μM) against extracellular promastigotes and intracellular amastigotes form of Leishmania donovani. Two promising compounds 22 and 37 were tested in vivo in L. donovani/hamster model. Chalcone 37 showed 83.32% parasite inhibition at a dose of 50 mg/kg for 10 days whereas, 75.89% parasite inhibition at 100 mg/kg dose for 5 days by intraperitoneal route at day 7 post-treatment.

A new route to the synthesis of pyranoflavone and pyranochalcone natural products and their derivatives

The total synthesis of biologically active pyranoflavone natural products 1 and 2 was carried out starting from 2H-pyran. The synthesis of pyranochalcone natural products, lonchocarpin (9) and 4-hydroxylonchocarpin (10), and their derivatives 30-32 is des

Selenium-based solid-phase synthesis of benzopyrans I: Applications to combinatorial synthesis of natural products

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