1615709-89-1

Basic information

• Product Name: 1-benzyl-4-methyl-3-(methylamino)pyridinium bromide
• Synonyms: 1-benzyl-4-methyl-3-(methylamino)pyridinium bromide
• CAS NO: 1615709-89-1
• Molecular Weight: 293.206
• Mol File: 1615709-89-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-methyl-3-(methylamino)pyridinium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-methyl-3-(methylamino)pyridinium bromide(1615709-89-1)
• EPA Substance Registry System: 1-benzyl-4-methyl-3-(methylamino)pyridinium bromide(1615709-89-1)

Safety Data

• Hazardous Substances Data: 1615709-89-1(Hazardous Substances Data)

Usage

Chemical classification

Quaternary ammonium salt

Function

Selective inhibitor of NAD-dependent enzymes

Target enzyme

Nicotinamide N-methyltransferase (NNMT)

NNMT involvement

Metabolism of compounds, including drugs, xenobiotics, and endogenous substances

Therapeutic potential

Cancer and metabolic disorders

Physiological role

Modulating NAD-dependent enzymes function

Research applications

Tool compound for studying biochemical and physiological roles of NNMT and related enzymes in cellular and animal models

Upstream product

• 72093-04-0 3-chloro-4-methylpyridine 
• 100-39-0 benzyl bromide 
• 77862-24-9 4-Methyl-3-(methylamino)pyridine 
• 694495-63-1 O-methyl-N-(4-methylpyridin-3-yl)carbamate 
• 3430-27-1 3-amino-4-methylpyridine 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 108-89-4 picoline 
• 1615709-86-8 1-benzyl-3-bromo-4-methylpyridinium bromide 
• 74-89-5 methylamine 

Downstream Products

• 384338-23-2 (1-benzyl-4-methyl-piperidin-3-yl)-methyl-amine 
• 1228879-37-5 cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine bis(hydrochloride) 
• 1354621-59-2 cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine 
• 477600-70-7 N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine 

Relevant articles and documents

Synthesis method for preparing intermediates of tofacitinib

The invention provides a novel method for synthesizing primary ring cis-4-methyl-3-methylamino-1-benzylpiperidine bis-hydrochloride of tofacitinib. The primary ring cis-4-methyl-3-methylamino-1-benzylpiperidine bis-hydrochloride is made from 3-halogenation-picoline. The novel method includes steps of catalytic Ullman coupling, 3-halogenation-picoline and benzyl halide salifying, hydroboration reagent reduction, salifying and the like to obtain target compounds. The method has the advantages of simple conditions, easily available reagents and operational safety.

A synthetic cis - 1 - benzyl - 3 - methylamino - 4 - methyl - piperidine

The invention relates to a method for synthesizing cis-1-benzyl-3-methylamino-4-methyl-piperidine, in particular to a method for synthesizing cis-1-benzyl-3-methylamino-4-methyl-piperidine by taking 1-benzyl-3-methylamino-4-methyl-piperidine bromide as an