161646-53-3

Basic information

• Product Name: Carbamic acid, [1-iodo-4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester
• CAS NO: 161646-53-3
• Molecular Formula: C22H22INO3
• Molecular Weight: 475.326
• Mol File: 161646-53-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [1-iodo-4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1-iodo-4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester(161646-53-3)
• EPA Substance Registry System: Carbamic acid, [1-iodo-4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester(161646-53-3)

Safety Data

• Hazardous Substances Data: 161646-53-3(Hazardous Substances Data)

Upstream product

• 34205-71-5 methyl 4-hydroxy-2-naphthalenecarboxylate 
• 100-39-0 benzyl bromide 
• 139975-98-7 tert-butyl-(4-hydroxynaphthalen-2-yl)carbamate 
• 132-86-5 1,3-dihydroxynaphthalene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 122745-36-2 N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine 
• 501440-80-8 3-(N-tert-butyloxycarbonyl)amino-1-O-(tertbutyloxycarbonyl)-1-naphthol 
• 2764-95-6 4-methoxy-2-naphthylamine 

Downstream Products

• 161646-54-4 2-<amino>-4-(benzyloxy)-1-iodonaphthalene 
• 191732-51-1 N-BOC-6-benzyloxy-3,4-dihydrobenzo[f]quinoline 
• 194221-83-5 4-(Benzyloxy)-N-(tert-butyloxycarbonyl)-1-iodo-N-(4-penten-1-yl)-2-naphthylamine 
• 122745-40-8 tert-Butyl(S)-5-(benzyloxy)-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 194221-94-8 7-Benzyloxy-1-methylene-1,2,3,4-tetrahydro-naphtho[2,1-b]azepine-5-carboxylic acid methyl ester 
• 194221-97-1 7-Benzyloxy-1-hydroxymethyl-1,2,3,4-tetrahydro-naphtho[2,1-b]azepine-5-carboxylic acid methyl ester 
• 194221-84-6 7-Benzyloxy-1-methylene-1,2,3,4-tetrahydro-naphtho[2,1-b]azepine-5-carboxylic acid tert-butyl ester 
• 194221-89-1 7-Benzyloxy-1-chloromethyl-1,2,3,4-tetrahydro-naphtho[2,1-b]azepine-5-carboxylic acid tert-butyl ester 
• 194221-85-7 7-Benzyloxy-1-hydroxymethyl-1,2,3,4-tetrahydro-naphtho[2,1-b]azepine-5-carboxylic acid tert-butyl ester 
• 194221-99-3 7-Benzyloxy-1-methanesulfonyloxymethyl-1,2,3,4-tetrahydro-naphtho[2,1-b]azepine-5-carboxylic acid methyl ester 
• 194221-96-0 (7-Benzyloxy-1-methylene-1,2,3,4-tetrahydro-naphtho[2,1-b]azepin-5-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanone 
• 194222-00-9 Methanesulfonic acid 7-benzyloxy-5-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3,4,5-tetrahydro-1H-naphtho[2,1-b]azepin-1-ylmethyl ester 
• 194221-87-9 7-Benzyloxy-1-methanesulfonyloxymethyl-1,2,3,4-tetrahydro-naphtho[2,1-b]azepine-5-carboxylic acid tert-butyl ester 
• 194221-98-2 (7-Benzyloxy-1-hydroxymethyl-1,2,3,4-tetrahydro-naphtho[2,1-b]azepin-5-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanone 

Relevant articles and documents

CYTOTOXIC AGENTS

The present invention provides a compound of formula (I): (T-X4)p-B1-X3-A-X2-L-X1-AM or pharmaceutically acceptable salts, tautomers, stereoisomers or mixtures thereof; wherein AM is (AM1); (AM2); or (AM3); with the proviso that the compound of formula (I) contains at least one sigma hole group; and with the proviso that no more than one of A, B1 and T is a sigma hole group; and each sigma hole group is independently: (SH1); (SH2); (SH3); (SH4); (SH5); (SH6); (SH7); (SH8); (SH9); or (SH10).

ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS

Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.

CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.