1616775-82-6Relevant articles and documents
Base mediated synthesis of α-aminated aroyl/acetylnaphthalenes through [4+2] annulations
Singh, Surjeet,Althagafi, Ismail,Yadav, Pratik,Panwar, Rahul,Kumar, Abhinav,Pratap, Ramendra
, p. 8879 - 8884 (2014)
We have developed a base promoted simple, efficient and alternative approach for the synthesis of 4-amino-3-aroyl//heteroaroyl/acetyl-2-methylsulfanyl-naphthalene-1-carbonitriles by reaction of easily accessible 3,3-bis(methylthio)-1-aryl/heteroaryl/acety
Synthesis of 1-amino-2-aroyl/acetylnaphthalenes through a base mediated one pot inter and intramolecular C-C bond formation strategy
Singh, Surjeet,Yadav, Pratik,Sahu, Satya Narayan,Althagafi, Ismail,Kumar, Abhinav,Kumar, Brijesh,Ram, Vishnu Ji,Pratap, Ramendra
, p. 4730 - 4737 (2014/06/24)
A new precursor 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile has been synthesized by the reaction of 2-cyanomethylbenzonitrile, carbon disulfide and methyl iodide under basic conditions. The reaction of 2-(1-cyano-2,2- bis(methylthio)vinyl)benzonitrile with various functionalized aryl/heteroaryl methyl ketones or acetone under basic conditions afforded 4-amino-3-aroyl/ heteroaroyl/acetyl-2-methylsulfanylnaphthalene-1-carbonitriles in good yields through a (5C + 1C) annulation strategy; this involves sequential intermolecular, followed by intramolecular, C-C bond formation reactions. The structure of the product was confirmed by single crystal X-ray crystallography. This journal is
