1616776-05-6

Basic information

• Product Name: 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile
• Synonyms: 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile
• CAS NO: 1616776-05-6
• Molecular Weight: 246.357
• Mol File: 1616776-05-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile(1616776-05-6)
• EPA Substance Registry System: 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile(1616776-05-6)

Safety Data

• Hazardous Substances Data: 1616776-05-6(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 3759-28-2 (2-cyanophenyl)acetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 1616775-96-2 4-amino-3-benzoyl-2-(pyrrolidin-1-yl)naphthalene-1-carbonitrile 
• 1616775-93-9 4-amino-3-(4-fluorobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile 
• 1616775-95-1 4-amino-2-methylsulfanyl-3-(4-methylsulfanylbenzoyl)naphthalene-1-carbonitrile 
• 1616775-94-0 4-amino-3-(4-chlorobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile 
• 1616775-82-6 4-amino-3-benzoyl-2-(methylsulfanyl)naphthalene-1-carbonitrile 
• 1616775-83-7 4-amino-3-(4-methylbenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile 
• 1616776-01-2 2-(1-cyano-2-methylsulfanyl-2-(pyrrolidin-1-yl)vinyl)benzonitrile 
• 1616776-00-1 2-(1-cyano-2,2-di(pyrrolidin-1-yl)vinyl)benzonitrile 
• 1616775-84-8 4-amino-3-(4-methoxybenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile 
• 1616775-85-9 4-amino-3-(4-bromobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile 
• 1616775-86-0 4-amino-3-(2-bromobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile 
• 1616775-87-1 3-(2-allyloxybenzoyl)-4-amino-2-(methylsulfanyl)naphthalene-1-carbonitrile 

Relevant articles and documents

Synthesis of arylated and aminated naphthalenes and their synthetic applications for aza-heterocycles

We have developed a new, metal free methodology for the synthesis of 3,4-diamino-2-methylsulfanyl-naphthalene-1-carbonitrile by reaction of 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile and nitromethane under basic conditions followed by reduction of n

Synthesis of 1-amino-2-aroyl/acetylnaphthalenes through a base mediated one pot inter and intramolecular C-C bond formation strategy

A new precursor 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile has been synthesized by the reaction of 2-cyanomethylbenzonitrile, carbon disulfide and methyl iodide under basic conditions. The reaction of 2-(1-cyano-2,2- bis(methylthio)vinyl)benzonitrile with various functionalized aryl/heteroaryl methyl ketones or acetone under basic conditions afforded 4-amino-3-aroyl/ heteroaroyl/acetyl-2-methylsulfanylnaphthalene-1-carbonitriles in good yields through a (5C + 1C) annulation strategy; this involves sequential intermolecular, followed by intramolecular, C-C bond formation reactions. The structure of the product was confirmed by single crystal X-ray crystallography. This journal is