1616775-85-9

Basic information

• Product Name: 4-amino-3-(4-bromobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile
• Synonyms: 4-amino-3-(4-bromobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile
• CAS NO: 1616775-85-9
• Molecular Weight: 397.295
• Mol File: 1616775-85-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-amino-3-(4-bromobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-3-(4-bromobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile(1616775-85-9)
• EPA Substance Registry System: 4-amino-3-(4-bromobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile(1616775-85-9)

Safety Data

• Hazardous Substances Data: 1616775-85-9(Hazardous Substances Data)

Upstream product

• 3759-28-2 (2-cyanophenyl)acetonitrile 
• 39580-38-6 1-(4-bromophenyl)-3,3-bis(methylthio)prop-2-en-1-one 
• 1616776-05-6 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile 
• 99-90-1 para-bromoacetophenone 

Relevant articles and documents

Synthesis, biological evaluation and molecular docking study of 1-amino-2-aroylnaphthalenes against prostate cancer

A series of functionalized naphthalene was synthesized and screened against human prostate cancer cell line (PC-3). The in vitro antiproliferative activity of the synthesized compounds was evaluated by monitoring their cytotoxic effects against PC-3 cells by using MTT assay. We observed that compound 5f resulted in more than 50% cell death at 14 μM. Treatment of PC-3 cells with 5f provides apoptosis by flow cytometry. Western blotting showed decreased expression of pro-caspase 8 and 9. Our study shows that cancer cell treated with 5f has higher concentration of reactive oxygen species as compare to untreated sample, which facilitate cancerous cell to enter apoptosis. Exact mechanism by which ROS is generated after 5f treatment is still under study. Molecular docking study further strengthens the results obtained from in vitro experiments. Compound 5f can be considered as a promising leads for anticancer agent against prostate cancer cells due to its potent cytotoxic activity and apoptotic effect.

Base mediated synthesis of α-aminated aroyl/acetylnaphthalenes through [4+2] annulations

We have developed a base promoted simple, efficient and alternative approach for the synthesis of 4-amino-3-aroyl//heteroaroyl/acetyl-2-methylsulfanyl-naphthalene-1-carbonitriles by reaction of easily accessible 3,3-bis(methylthio)-1-aryl/heteroaryl/acety