162147-97-9

Basic information

• Product Name: 2-Butanone, 1-chloro-4-phenyl-1-(phenylsulfinyl)-
• CAS NO: 162147-97-9
• Molecular Formula: C16H15ClO2S
• Molecular Weight: 306.813
• Mol File: 162147-97-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 1-chloro-4-phenyl-1-(phenylsulfinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 1-chloro-4-phenyl-1-(phenylsulfinyl)-(162147-97-9)
• EPA Substance Registry System: 2-Butanone, 1-chloro-4-phenyl-1-(phenylsulfinyl)-(162147-97-9)

Safety Data

• Hazardous Substances Data: 162147-97-9(Hazardous Substances Data)

Upstream product

• 51620-80-5 4-phenyl-1-(phenylsulfinyl)-2-butanone 
• 7205-94-9 chloromethyl phenyl sulfoxide 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 930-69-8 sodium thiophenolate 
• 33840-74-3 1-(phenylsulfinyl)propan-2-one 
• 5042-53-5 1-(phenylsulfanyl)acetone 

Downstream Products

• 1821-12-1 4-Phenylbutyric acid 
• 56379-64-7 phenyl 4-phenylbutanoate 
• 16537-11-4 tert-butyl 4-phenylbutanoate 
• 358349-85-6 isopropyl 4-phenylbutanoate 
• 41208-51-9 4-phenyl-1-(piperidin-1-yl)butan-1-one 
• 20845-80-1 1-chloro-4-phenylbutan-2-one 
• 2046-17-5 methyl 3-(benzyl)propanoate 

Relevant articles and documents

Dianion of sulfinylacetone as a synthetic equivalent of β-enolate of propionic acid: A novel synthesis of carboxylic acids from alkyl halides with three-carbon elongation

The reaction of the dianion of phenylsulfinylacetone with alkyl halides afforded β-keto sulfoxides, which were first chlorinated with hexachloroethane and then treated successively with KH and t-BuLi to give carboxylic acids in three-steps in moderate overall yields from the alkyl halides. This procedure affords a good method for a synthesis of carboxylic acids from alkyl halides with three-carbon elongation.

Ligand exchange reaction of sulfoxides in organic synthesis: A new method for one-carbon homologation of esters to carboxylic acids and esters via α- chloro α-sulfinyl ketones

Reaction of the Carbanion of chloromethyl phenyl sulfoxide with esters gave α-chloro α-sulfinyl ketones, which were treated with KH followed by t- BuLi to afford one-carbon homologated acids and esters in good to excellent yields.