1622923-42-5 Usage
Description
Potassium 3-ethoxycarbonylbenzoyltrifluoroborate, also known as KAT, is a stable reagent derived from acyltrifluoroborates. It is characterized by its ability to form amide bonds rapidly and chemoselectively with hydroxylamines. KAT exhibits bench, air, and moisture stability, making it a reliable compound for various applications in the chemical and pharmaceutical industries.
Uses
Used in Chemical Synthesis:
Potassium 3-ethoxycarbonylbenzoyltrifluoroborate is used as a reagent for rapid and chemoselective amide bond formation with hydroxylamines. Its application is particularly valuable in chemical synthesis due to its stability and the fact that it does not require coupling reagents or protecting groups, simplifying the process and reducing the need for additional steps.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, potassium 3-ethoxycarbonylbenzoyltrifluoroborate is used as a key component in the development of new drugs. Its ability to form amide bonds under aqueous conditions without the need for additional reagents or protection groups makes it an attractive option for drug synthesis, potentially leading to more efficient and cost-effective production processes.
Used in Research and Development:
Potassium 3-ethoxycarbonylbenzoyltrifluoroborate is also utilized in research and development settings, where its stability and reactivity make it a valuable tool for exploring new chemical reactions and applications. The product was introduced in collaboration with the Bode Research Group, highlighting its potential for further scientific advancements and discoveries.
Check Digit Verification of cas no
The CAS Registry Mumber 1622923-42-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,2,9,2 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1622923-42:
(9*1)+(8*6)+(7*2)+(6*2)+(5*9)+(4*2)+(3*3)+(2*4)+(1*2)=155
155 % 10 = 5
So 1622923-42-5 is a valid CAS Registry Number.
1622923-42-5Relevant articles and documents
A reagent for the one-step preparation of potassium acyltrifluoroborates (KATs) from aryl- and heteroarylhalides
Eroes, Gabor,Kushida, Yo,Bode, Jeffrey W.
supporting information, p. 7604 - 7607 (2014/08/05)
Potassium acyltrifluoroborates (KATs) are fascinating functional groups whose further exploration is limited by poor synthetic access. Documented herein is the design and synthesis of a new reagent for their one-step preparation from aryl- and heteroarylhalides. The reagent is a stable, soluble zwitterion prepared by S-alkylation of a novel thioformamide trifluoroboronate. The KATs are prepared by adding one equivalent of nBuLi to a mixture of the aryl halide and the reagent at -78 C. This protocol is suitable for the preparation of KATs containing pyridines, esters, nitro groups, and halides.
