1622923-55-0 Usage
Description
Potassium 6-chloro-2-isonicotinoyltrifluoroborate is a stable trifluoroborate salt that belongs to the class of compounds known as potassium acyltrifluroborates (KATs). It is characterized by its resistance to trimerization and is used in the formation of amide bonds with hydroxylamines.
Uses
Used in Pharmaceutical Industry:
Potassium 6-chloro-2-isonicotinoyltrifluoroborate is used as a reagent for rapid, chemoselective amide bond formations with hydroxylamines. This application is particularly useful in the synthesis of various pharmaceutical compounds, as it allows for the formation of these bonds under aqueous conditions without the need for coupling reagents or protecting groups.
Used in Chemical Research:
In the field of chemical research, potassium 6-chloro-2-isonicotinoyltrifluoroborate is used as a bench, air, and moisture stable reagent. Its stability and ability to form amide bonds under mild conditions make it a valuable tool for researchers working with hydroxylamines and related compounds.
This product was introduced in collaboration with the Bode Research Group, further emphasizing its importance and potential applications in both pharmaceutical and chemical research industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1622923-55-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,2,9,2 and 3 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1622923-55:
(9*1)+(8*6)+(7*2)+(6*2)+(5*9)+(4*2)+(3*3)+(2*5)+(1*5)=160
160 % 10 = 0
So 1622923-55-0 is a valid CAS Registry Number.
1622923-55-0Relevant articles and documents
A reagent for the one-step preparation of potassium acyltrifluoroborates (KATs) from aryl- and heteroarylhalides
Eroes, Gabor,Kushida, Yo,Bode, Jeffrey W.
supporting information, p. 7604 - 7607 (2014/08/05)
Potassium acyltrifluoroborates (KATs) are fascinating functional groups whose further exploration is limited by poor synthetic access. Documented herein is the design and synthesis of a new reagent for their one-step preparation from aryl- and heteroarylhalides. The reagent is a stable, soluble zwitterion prepared by S-alkylation of a novel thioformamide trifluoroboronate. The KATs are prepared by adding one equivalent of nBuLi to a mixture of the aryl halide and the reagent at -78 C. This protocol is suitable for the preparation of KATs containing pyridines, esters, nitro groups, and halides.
