1637572-64-5

Basic information

• Product Name: 6-(tert-butyl)-2-methoxy-3,4-diphenylisoquinolin-1(2H)-one
• Synonyms: 6-(tert-butyl)-2-methoxy-3,4-diphenylisoquinolin-1(2H)-one
• CAS NO: 1637572-64-5
• Molecular Weight: 383.49
• Mol File: 1637572-64-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-(tert-butyl)-2-methoxy-3,4-diphenylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(tert-butyl)-2-methoxy-3,4-diphenylisoquinolin-1(2H)-one(1637572-64-5)
• EPA Substance Registry System: 6-(tert-butyl)-2-methoxy-3,4-diphenylisoquinolin-1(2H)-one(1637572-64-5)

Safety Data

• Hazardous Substances Data: 1637572-64-5(Hazardous Substances Data)

Upstream product

• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 57139-24-9 4-(tert-butyl)-N-methoxybenzamide 
• 501-65-5 diphenyl acetylene 

Relevant articles and documents

Metal-free iodine(III)-promoted synthesis of isoquinolones

A metal-free oxidative cycloaddition reaction of substituted benzamides and alkynes has been developed for the synthesis of isoquinolones by using bis(trifluoracetoxy)iodobenzene (PIFA) and trifluoroacetic acid (TFA). Under mild conditions, a wide variety of isoquinolones were conveniently prepared via oxidative annulation of simple N-methoxybenzamide and diarylacetylene or aryl/alkyl acetylene derivatives in yields up to 87%.

Pd/C-catalyzed synthesis of isoquinolones through C-H Activation

The direct synthesis of isoquinolones from benzamides and alkynes through C-H activation was developed by using Pd/C as a heterogeneous catalyst without a ligand under mild conditions. A variety of isoquinolones were obtained in good yields with excellent regioselectivities. The Pd/C catalyst could be recycled three times without a significant decrease in the activity (yields as high as 85). Activation complete: The direct synthesis of isoquinolones from benzamides and alkynes through C-H activation is developed by using Pd/C as a heterogeneous catalyst. The Pd/C catalyst can be recycled three times without a significant decrease in the activity.