57139-24-9

Basic information

• Product Name: 4-(tert-butyl)-N-methoxybenzamide
• Synonyms: 4-(tert-butyl)-N-methoxybenzamide
• CAS NO: 57139-24-9
• Molecular Weight: 207.272
• Mol File: 57139-24-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 4-(tert-butyl)-N-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-butyl)-N-methoxybenzamide(57139-24-9)
• EPA Substance Registry System: 4-(tert-butyl)-N-methoxybenzamide(57139-24-9)

Safety Data

• Hazardous Substances Data: 57139-24-9(Hazardous Substances Data)

Upstream product

• 57139-35-2 (Z)-O-methyl-p-(t-butyl)-benzohydroximoyl chloride 
• 593-56-6 N-methoxylamine hydrochloride 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 67-62-9 O-Methylhydroxylamin 

Downstream Products

• 1346684-66-9 6-(tert-butyl)-3,4-diphenylisoquinolin-1(2H)-one 
• 1354694-12-4 (E)-butyl 3-(5-tert-butyl-2-carbamoylphenyl)acrylate 
• 1380546-65-5 4-tert-butyl-2-(3-butylhept-2-enyl)-N-methoxybenzamide 
• 1637572-64-5 6-(tert-butyl)-2-methoxy-3,4-diphenylisoquinolin-1(2H)-one 
• 26537-19-9 methyl 4-tert-butylbenzoate 
• 31592-52-6 6-(tert-butyl)-3,4-diphenyl-1H-isochromen-1-one 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 

Relevant articles and documents

Pd(II)-catalyzed annulation reactions of epoxides with benzamides to synthesize isoquinolones

Epoxides as alkylating reagents are unprecedentedly applied in Pd(II)-catalyzed C?H alkylation and oxidative annulation of substituted benzamides to synthesize isoquinolones rather than isochromans, which is accomplished through alerting the previously reported reaction mechanism by the addition of oxidant and TEA. Under these conditions, various isoquinolones have been prepared with yields up to 92%. In addition, this methodology has been successfully employed in the total syntheses of rupreschstyril, siamine, and cassiarin A in an expedient fashion.

Palladium-Catalyzed Inert C?H Bond Activation and Cyclocarbonylation of Isoquinolones with Carbon Dioxide Leading to Isoindolo[2,1-b]isoquinoline-5,7-Diones

A palladium-catalyzed inert C?H bond activation and cyclocarbonylation of isoquinolones leading to isoindolo[2,1-b]isoquinoline-5,7-diones under 1 atm of carbon dioxide has been developed. This transformation features high regio- and chemo-selectivity, step-economy, and good functional group tolerance. Most of the corresponding products were obtained in moderate to good yields. It offers an alternative approach for the synthesis of useful diverse isoindolo[2,1-b]isoquinoline-5,7-dione derivatives. (Figure presented.).

C-F bond cleavage enabled redox-neutral [4+1] annulation via C-H bond activation

Using α,α-difluoromethylene alkyne as a nontraditional one-carbon reaction partner, a synthetically novel method for the construction of isoindolin-1-one derivatives via Rh(III)-catalyzed [4+1] annulation reaction is reported. The 2-fold C-F bond cleavage not only enables the generation of desired product under an overall oxidant-free condition but also results in a net migration of carbon-carbon triple bond. In addition, the present reaction protocol exhibits a tolerance of a wide spectrum of functional groups due to the mild reaction conditions employed.