1643330-62-4

Basic information

• Product Name: 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide
• Synonyms: 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide
• CAS NO: 1643330-62-4
• Molecular Formula: C20H26ClN3O3
• Molecular Weight: 391.89174
• Mol File: 1643330-62-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 626.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.282±0.06 g/cm3(Predicted)
• PKA: 14.38±0.70(Predicted)
• CAS DataBase Reference: 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide(1643330-62-4)
• EPA Substance Registry System: 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide(1643330-62-4)

Safety Data

• Hazardous Substances Data: 1643330-62-4(Hazardous Substances Data)

Usage

Description

5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide is a chemical compound with a complex structure, characterized by its chloro and pentanamide functional groups, as well as a morpholino-dihydropyridine moiety. 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide is likely to have specific interactions with biological targets due to its unique structural features.

Uses

Used in Pharmaceutical Industry:
5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide is used as an impurity in the production of Apixaban (503612-47-3 #CAS), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. Apixaban is a potential new oral coagulant useful for the prevention of venous thromboembolism in total hip and knee replacement orthopedic surgeries, as well as in the treatment of patients with venous thromboembolic disorder or atrial fibrillation.
Used in Medical Applications:
5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide is used as a compound for the development of new oral anticoagulants, specifically targeting coagulation factor Xa. This application is important for the treatment and prevention of various blood clot-related conditions, such as deep vein thrombosis, pulmonary embolism, and stroke, in patients with atrial fibrillation or undergoing orthopedic surgeries.

Upstream product

• 4789-09-7 1-phenylpiperidin-2-one 
• 62-53-3 aniline 
• 91131-23-6 5-chloro-pentanoic acid phenylamide 
• 881386-01-2 3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one 
• 503615-03-0 3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 
• 38560-30-4 1-(4-nitrophenyl)piperidine-2-one 
• 1039914-85-6 5-chloro-N-(4-nitrophenyl)pentanamide 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 100-01-6 4-nitro-aniline 
• 1267610-26-3 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one 

Relevant articles and documents

Preparation method of apixaban intermediate suitable for industrial production

The invention discloses a synthesis method of an apixaban intermediate suitable for industrial production. The method comprises the following steps: carrying out phase-transfer catalytic amidation reaction on paranitroaniline and 5-chlorovaleryl chloride in an organic phase and water phase two-phase system under an inorganic weakly alkaline condition to obtain an APM01 solution, and adding a sodium hydroxide water solution, and cyclizing in a pot to obtain an APM02 solution; directly carrying out alpha-reactive hydrogen dichlorination on an APM02 organic solution and phosphorus pentachloride after simple acid pickling, liquid separation and drying to obtain an APM03 solution; carrying out condensation-elimination reaction on the APM03 solution and excessive morpholine after simple acid pickling and liquid separation, and carrying out simple crystallization and purification treatment to separate out an APM04 solid, and reducing the APM04 into APM05 by sodium sulfide; and carrying out amidation-cyclization two-step one-pot reaction on the APM05 and 5-chlorovaleryl chloride to prepare a key intermediate APM07. According to the method, the synthesis efficiency of the apixaban intermediate is improved, the reaction is mild, and dangerous NaH and other expensive reagents are not used, so that the production cost is saved, the operation is simple, and the method is suitable for industrial popularization.

A pyridine derivative

The present invention relates to the field of pharmaceutical chemistry, specifically to a class of compounds containing lactam and derivative thereof, and especially to a pyridine derivative as shown in general formula (I), preparation method and the use thereof as a Factor Xa inhibitor. The present invention further relates to the medical use of the compound and derivative thereof in preparation of anticoagulant drugs, particularly to the use in preparation of drugs for preventing or treating thrombosis or embolism.