91131-23-6

Basic information

• Product Name: 5-chloro-pentanoic acid phenylamide
• Synonyms: 5-chloro-pentanoic acid phenylamide
• CAS NO: 91131-23-6
• Molecular Weight: 211.691
• Mol File: 91131-23-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-chloro-pentanoic acid phenylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-pentanoic acid phenylamide(91131-23-6)
• EPA Substance Registry System: 5-chloro-pentanoic acid phenylamide(91131-23-6)

Safety Data

• Hazardous Substances Data: 91131-23-6(Hazardous Substances Data)

Upstream product

• 1119-46-6 5-chloro-valeric acid 
• 62-53-3 aniline 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 89893-39-0 5-chloro-1-ethoxypent-1-yne 

Downstream Products

• 879216-05-4 5-azido-pentanoic acid phenylamide 
• 503614-91-3 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 
• 881386-01-2 3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one 
• 1643330-62-4 5-chloropentanoic acid [4-(5-morpholin-4-yl-6-oxo-3,6-dihydro-2H-pyridin-1-yl)phenyl]amide 
• 545445-44-1 5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone 
• 1267610-26-3 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one 
• 503615-03-0 3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 
• 38560-30-4 1-(4-nitrophenyl)piperidine-2-one 
• 1432672-07-5 N-phenyl-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pentanamide 
• 100134-63-2 5-cyano-N-phenylpentanamide 
• 100051-07-8 N-phenyl-pentamethylenediamine 
• 4789-09-7 1-phenylpiperidin-2-one 
• 159383-54-7 2-chloro-3-(3-chloro)propylquinoline 
• 142326-29-2 5-iodo-valeric acid anilide 

Relevant articles and documents

Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification

Genome mining of microbial natural products enables chemists not only to discover the bioactive molecules with novel skeletons, but also to identify the enzymes that catalyze diverse chemical reactions. Exploring the substrate promiscuity and catalytic mechanism of those biosynthetic enzymes facilitates the development of potential biocatalysts. SfaB is an acyl adenylate-forming enzyme that adenylates a unique building block, 3-isocyanobutanoic acid, in the biosynthetic pathway of the diisonitrile natural product SF2768 produced by Streptomyces thioluteus, and this AMP-ligase was demonstrated to accept a broad range of short-chain fatty acids (SCFAs). Herein, we repurpose SfaB to catalyze amidation or thioesterification between those SCFAs and various amine or thiol nucleophiles, thereby providing an alternative enzymatic approach to prepare the corresponding amides and thioesters in vitro.

A method of preparing intermediates [...]

A disclosed preparation method for an apixaban intermediate comprises the following steps: step (1), performing an amidation reaction shown in the specification on a compound 3 and a compound M in an organic solvent under the effect of an organic alkali to obtain a reaction solution containing a compound 3'; and step (2), under the effect of an inorganic base, directly performing an nucleophilic substitution reaction shown in the specification on the reaction solution obtained in the step (1) to prepare a compound 4, and performing a nitration reaction on the compound 4 under the effect of concentrated sulfuric acid and concentrated nitric acid to prepare a compound 5. The preparation method provided by the invention is low in cost, simple in operation and suitable for industrialization.

New synthetic routes for N-substituted 1,n-diamines. II. Synthesis of selectively N-substituted tetra- and pentamethylenediamines from ω-alkanoic acid derivatives

A new approach for the synthesis of selectively N-substituted tetra- and pentamethylenediamines 1 (n = 4,5) is described. The method uses N-substituted ω-haloalkanamides 2 as precursors and involves the microwave-promoted conversion into ω-azidocarboxamides 3 and later the reduction of both azido and carboxamide groups with diborane.