16437-69-7

Basic information

• Product Name: ACETIC ACID METHYLTHIOMETHYL ESTER
• Synonyms: METHYLTHIOMETHYL ACETATE;ACETIC ACID METHYLTHIOMETHYL ESTER;(Methylthio)-methanol1-acetate;1-(Methylthio)-methanol1-acetate
• CAS NO: 16437-69-7
• Molecular Formula: C₄H₈O₂S
• Molecular Weight: 120.17
• Mol File: 16437-69-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 62 °C / 20mmHg
• Flash Point: 51°C
• Appearance: /
• Density: 1,09 g/cm3
• Vapor Pressure: 3.03mmHg at 25°C
• Refractive Index: 1.4547
• CAS DataBase Reference: ACETIC ACID METHYLTHIOMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: ACETIC ACID METHYLTHIOMETHYL ESTER(16437-69-7)
• EPA Substance Registry System: ACETIC ACID METHYLTHIOMETHYL ESTER(16437-69-7)

Safety Data

• Statements: 10-36/37/38
• Safety Statements: 16-37-26
• RIDADR: 3272
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 16437-69-7(Hazardous Substances Data)

Usage

General Description

Acetic acid methylthiomethyl ester, also known as methylthiomethyl acetate, is a chemical compound commonly used in the production of flavors and fragrances. It is a clear, colorless liquid with a pungent odor, and is often used as a solvent in various industrial applications. ACETIC ACID METHYLTHIOMETHYL ESTER is also a key intermediate in the synthesis of pharmaceuticals and other organic compounds, making it an important building block in chemical manufacturing. It is important to handle acetic acid methylthiomethyl ester with care, as it can be irritating to the skin, eyes, and respiratory system if not properly managed.

InChI:InChI=1/C4H8O2S/c1-4(5)6-3-7-2/h3H2,1-2H3

Upstream product

• 75-18-3 dimethylsulfide 
• 108-24-7 acetic anhydride 
• 506-96-7 Acetyl bromide 
• 67-68-5 dimethyl sulfoxide 
• 21603-22-5 1-carbomethoxy-3,3-dimethylcyclopropene 
• 546-67-8 lead(IV) tetraacetate 
• 78-79-5 isoprene 
• 67-63-0 isopropyl alcohol 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 32810-66-5 N-acetyl dimethylsulfimide 
• 71-43-2 benzene 
• 67-66-3 chloroform 

Downstream Products

• 95390-50-4 Dimethyl-acetoxymethyl-sulfonium 
• 1618-26-4 2,4-dithiapentane 
• 5925-86-0 (4-methoxybenzyl)methylsulfide 
• 104-21-2 p-methoxybenzyl acetate 
• 81077-60-3 o-methylthiomethylanisole 

Relevant articles and documents

Convenient Preparation of Methylthiomethyl p-Tolyl Sulfone Starting from Dimethyl Sulfoxide

An efficient method for preparing methylthiomethyl p-tolyl sulfone was accomplished by the Pummerer reaction of dimethyl sulfoxide with acetic anhydride followed by treatment of the resulting acetoxymethyl methyl sulfide with sodium p-toluenesulfinate in the presence of sodium acetate in acetic acid.

Direct introduction of CH2SMe group in aromatic ring

Application as a reagent of an accessible methylthiomethyl acetate in a reaction carried out under two-phase conditions and electrophilic catalysis can become a promising procedure for preparation of methylthiomethyl-substituted arenes.

Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs

Heat-sensitive thiophosphate protecting groups derived from the alcohol 4 or 10 have provided insights in the design of DNA oligonucleotide prodrugs. Indeed, functional groups stemming from the alcohol 9, 15, 16 or 22 may be applicable to thiophosphate protection of immunostimulatory CpG DNA motifs, whereas those originating from the alcohol 3, 5, 12, 13, 18, 20 or 22 offer adequate protection of terminal phosphodiester functions against ubiquitous exonucleases that may be found in biological environments. Functional groups derived from the alcohol 9, 15, 16, 19 or 23 are suitable for the protection of phosphodiester functions flanking the CpG motifs of immunomodulatory DNA sequences.

Oxidative Decarboxylation of Some Bicyclohept-3-ene-1-carboxylic Acids

Treatment of the bicyclohept-3-ene-1-carboxylic acids (8d-f) with lead tetraacetate results in oxidative decarboxylation and formation of the 1-aryl-1-methylethyl acetates (12a-c).