1644034-05-8

Basic information

• Product Name: (R)-methyl 5-(4-methoxyphenyl)-3-methyl-5,6-dihydro-1,4-dioxine-2-carboxylate
• CAS NO: 1644034-05-8
• Molecular Weight: 264.278
• Mol File: 1644034-05-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-methyl 5-(4-methoxyphenyl)-3-methyl-5,6-dihydro-1,4-dioxine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 5-(4-methoxyphenyl)-3-methyl-5,6-dihydro-1,4-dioxine-2-carboxylate(1644034-05-8)
• EPA Substance Registry System: (R)-methyl 5-(4-methoxyphenyl)-3-methyl-5,6-dihydro-1,4-dioxine-2-carboxylate(1644034-05-8)

Safety Data

• Hazardous Substances Data: 1644034-05-8(Hazardous Substances Data)

Upstream product

• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 62600-73-1 (R)?4?methoxyphenyloxirane 

Relevant articles and documents

[CpRu]-catalyzed carbene insertions into epoxides: 1,4-dioxene synthesis through sn1-like chemistry with retention of configuration

Rather than lead to the usual deoxygenation pathway, metal carbenes derived from α-diazo-β-ketoesters undergo three-atom insertions into epoxides using a combination of 1,10-phenanthroline and [CpRu(CH 3CN)3][BArF] as the catalyst. Original 1,4-dioxene motifs are obtained as single regio- and stereoisomers. A perfect syn stereochemistry (retention, e.r. up to 97:3) is observed for the ring opening, which behaves as an SN1-like transformation.