166528-78-5Relevant articles and documents
Studies on the apoptotic activity of natural and synthetic retinoids: Discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells
Simoni, Daniele,Giannini, Giuseppe,Roberti, Marinella,Rondanin, Riccardo,Baruchello, Riccardo,Rossi, Marcello,Grisolia, Giuseppina,Invidiata, Francesco Paolo,Aiello, Stefania,Marino, Silvia,Cavallini, Sabrina,Siniscalchi, Anna,Gebbia, Nicola,Crosta, Lucia,Grimaudo, Stefania,Abbadessa, Vincenzo,Di Cristina, Antonietta,Tolomeo, Manlio
, p. 4293 - 4299 (2007/10/03)
New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.