127-47-9 Usage
Description
Retinyl acetate, also known as retinol acetate or vitamin A acetate, is a natural form of vitamin A and the acetate ester of retinol. It is characterized by its yellow crystalline appearance, greasy or sticky texture, and a mild, characteristic odor. Retinyl acetate possesses potential antineoplastic and chemo-preventive activities, making it a valuable compound in various applications.
Uses
Used in Pharmaceutical Industry:
Retinyl acetate is used as a vitamin precursor for its essential micronutrient properties, playing a crucial role in maintaining overall health and well-being.
Used in Food Fortification:
Retinyl acetate is used as a fortifying agent for food products, particularly to enhance the vitamin A content, which is essential for proper growth, development, and immune function.
Used in Skincare Products:
Retinyl acetate is used as a skin-conditioning agent due to its ability to induce cell differentiation and inhibit cell proliferation, making it beneficial for maintaining healthy skin.
Used in Research and Analysis:
Retinyl acetate has been used in various research applications, such as a control diet to study its effects at different developmental periods in fish larvae, and to study its inhibitory effects on Mycobacterium avium subspecies paratuberculosis (MAP) strains.
Used in Chromatography:
Retinyl acetate is used as an internal standard in high-performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk, ensuring accurate and reliable results in the analysis of vitamin A content.
Used in Analytical Chemistry:
Retinyl acetate is suitable for use in the retention identification of the analyte when using high-performance liquid chromatography (HPLC) and gas chromatography (GC), providing a reliable reference for quality assurance in these analytical techniques.
Reference
Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5
Flammability and Explosibility
Notclassified
Biochem/physiol Actions
Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.
Safety Profile
Moderately toxic by
ingestion. Experimental teratogenic and
reproductive effects. Questionable
carcinogen with experimental neoplastigenic
data. Mutation data reported. When heated
to decomposition it emits acrid smoke and
irritating fumes. See also VITAMIN A.
Purification Methods
The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]
Check Digit Verification of cas no
The CAS Registry Mumber 127-47-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 127-47:
(5*1)+(4*2)+(3*7)+(2*4)+(1*7)=49
49 % 10 = 9
So 127-47-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H30O3/c1-16(9-7-10-17(2)15-21(24)25-19(4)23)12-13-20-18(3)11-8-14-22(20,5)6/h7,9-10,12-13,15H,8,11,14H2,1-6H3/b10-7+,13-12+,16-9+,17-15+
127-47-9Relevant articles and documents
-
Planta,C. et al.
, p. 548 - 561 (1962)
-
Derguini et al.
, p. 4899,4900,4901 (1979)
PROCESS FOR PRODUCTION OF VITAMIN A
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Page/Page column 14, (2021/10/11)
The present invention relates to a new process for the production of vitamin A and/or its derivatives.
Preparation method of vitamin A acetate
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Paragraph 0017; 0047; 0049-0050; 0052-0053; 0055-0056; 0058, (2021/06/21)
The invention provides a novel preparation method of vitamin A acetate, which comprises the following steps: 1-bromo-2-chloroethane is subjected to in-situ preparation of a Grignard reagent, then the Grignard reagent reacts with pentacarbaldehyde to prepare 3-methyl-6-chloro-2, 4-hexadienol acetate, and the 3-methyl-6-chloro-2, 4-hexadienol acetate is subjected to one-step in-situ Grignard reaction and beta-ionone reaction to obtain the vitamin A acetate. The process provides a C13 + C7 vitamin A acetate synthesis route, generation of triphenylphosphine oxide is avoided, modification solid acid is used for catalysis, VA deterioration is avoided, the yield of the vitamin A acetate is improved, the process cost is reduced, the reaction process is environmentally friendly, and industrial production is facilitated. The process cost is reduced, the reaction process is environment-friendly, and industrial production is facilitated.