1669-49-4

Basic information

• Product Name: 3-(4-METHOXYPHENYL)PROPIOPHENONE
• Synonyms: 3-(4-METHOXYPHENYL)PROPIOPHENONE;3-(4-methoxyphenyl)-1-phenyl-propan-1-one;3-(4-methoxyphenyl)-1-phenylpropan-1-one
• CAS NO: 1669-49-4
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.3
• Mol File: 1669-49-4.mol
• Article Data: 179

Chemical Properties

• Boiling Point: 392°Cat760mmHg
• Flash Point: 175.1°C
• Appearance: /
• Density: 1.081g/cm³
• Vapor Pressure: 2.36E-06mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 3-(4-METHOXYPHENYL)PROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXYPHENYL)PROPIOPHENONE(1669-49-4)
• EPA Substance Registry System: 3-(4-METHOXYPHENYL)PROPIOPHENONE(1669-49-4)

Safety Data

• Hazardous Substances Data: 1669-49-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O2/c1-18-15-10-7-13(8-11-15)9-12-16(17)14-5-3-2-4-6-14/h2-8,10-11H,9,12H2,1H3

Upstream product

• 98-86-2 acetophenone 
• 105-13-5 4-Methoxybenzyl alcohol 
• 637-69-4 4-Methoxystyrene 
• 93-97-0 benzoic acid anhydride 
• 66324-10-5 tert-butyldimethyl(1-phenylvinyloxy)silane 
• 824-94-2 p-methoxybenzyl chloride 
• 873-76-7 para-Chlorobenzyl alcohol 
• 2393-23-9 4-methoxy-benzylamine 
• 202123-13-5 (4-methoxyphenyl)-N-(1-phenylethylidene)methanamine 
• 96-09-3 styrene oxide 
• 100-52-7 benzaldehyde 
• 4663-33-6 1,3-diphenyl-3-hydroxypropene 
• 94-41-7 benzalacetophenone 
• 14097-24-6 1,3-diphenylpropan-1-ol 

Downstream Products

• 1379005-12-5 C₂₀H₂₂O₃ 
• 33209-82-4 5-(4-methoxyphenyl)-2-methylpentan-1-ol 
• 1379005-13-6 ethyl 5-(4-methoxyphenyl)-3-phenylpentanoate 
• 95025-54-0 2-(4-methoxybenzyl)-3-phenylbenzofuran 
• 136-60-7 benzoic acid, butyl ester 
• 6946-35-6 butyl 4-methoxybenzoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 93-89-0 benzoic acid ethyl ester 
• 221915-87-3 1,1,1-trifluoro-4-(4-methoxy-phenyl)-butan-2-one 
• 1436413-28-3 C₂₃H₁₉NO 

Relevant articles and documents

Nickel-catalyzed α-alkylation of ketones with benzyl alcohols

We reported an efficient method for α-alkylation of ketones with benzyl alcohols using the pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts. A wide range of ketones and benzyl alcohols were efficiently converted into various alkylated products in moderate to high yields. In addition, these nickel complexes were also successfully applied for the synthesis of a wide range of quinoline derivatives.

Nickel-Catalyzed Selective Synthesis of α-Alkylated Ketones via Dehydrogenative Cross-Coupling of Primary and Secondary Alcohols

Herein, we describe an isolable, air-stable, homogeneous, nickel catalyst that performs dehydrogenative cross-coupling reaction between secondary and primary alcohols to result α-alkylated ketone products selectively. The sequence of steps involve in this one-pot reaction is dehydrogenation of both alcohols, condensation between the ketone and the aldehyde, and hydrogenation of the in situ-generated α,β-unsaturated ketone. Preliminary mechanistic investigation hints a radical mechanism following borrowing hydrogen reaction. (Figure presented.).

Synthesis of α-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols

A new method for converting terminal epoxides and primary alcohols into α-alkylated ketones under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcohols in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product.