1672-63-5

Basic information

• Product Name: 4-HYDROXYANTIPYRINE
• Synonyms: 4-HYDROXYANTIPYRINE;4-HYDROXY-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;1,5-Dimethyl-2-phenyl-4-hydroxy-4-pyrazoline-3-one;2,3-Dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-1H-pyrazol-3-one;4-hydroxy-1,5-dimethyl-2-phenyl-pyrazol-3-one;4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one;NSC 174055
• CAS NO: 1672-63-5
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• Product Categories: Heterocyclic Compounds
• Mol File: 1672-63-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 184-186 °C(lit.)
• Boiling Point: 314.3°Cat760mmHg
• Flash Point: 143.9°C
• Appearance: /
• Density: 1.294g/cm³
• Vapor Pressure: 0.000199mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 11.99±0.20(Predicted)
• CAS DataBase Reference: 4-HYDROXYANTIPYRINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYANTIPYRINE(1672-63-5)
• EPA Substance Registry System: 4-HYDROXYANTIPYRINE(1672-63-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1672-63-5(Hazardous Substances Data)

Usage

Description

4-Hydroxyantipyrine, a metabolite of antipyrine, is formed during the oxidative deamination of aminopyrine. Antipyrine, an analgesic and antipyretic, is used for oral and topical administration, such as in ear drops. It serves as a valuable tool in assessing the impact of other drugs or diseases on drug-metabolizing enzymes in the liver.

Uses

Used in Pharmaceutical Research:
4-Hydroxyantipyrine is used as a research compound for studying the metabolism of antipyrine, hexobarbitone, and theophylline in humans. It aids in understanding the relationships between these substances and their effects on drug-metabolizing enzymes in the liver.
Used in Analytical Chemistry:
4-Hydroxyantipyrine is utilized in flow injection analysis systems for the characterization of pharmaceutical compounds. This involves the combination of diode array UV, 1H NMR, FT-IR spectroscopy, and time-of-flight mass spectrometry techniques to analyze and identify the compound's properties and interactions.
Used in Drug Metabolism Studies:
4-Hydroxyantipyrine serves as a key metabolite in the study of antipyrine's metabolism, which is often used to test the effects of other drugs or diseases on liver enzymes responsible for drug metabolism. This helps researchers evaluate the liver's ability to process and eliminate various medications and substances.

InChI:InChI=1/C11H12N2O2/c1-8-10(14)11(15)13(12(8)2)9-6-4-3-5-7-9/h3-7,14H,1-2H3

Upstream product

• 2139-47-1 nifenazone 
• 60-80-0 antipyrine 
• 7732-18-5 water 
• 50-81-7 ascorbic acid 
• 68-89-3 metamizol 
• 6536-18-1 Morazone 
• 3615-24-5 ramifenazone 
• 58-15-1 aminopyrine 
• 479-92-5 propyphenazone 
• 5426-65-3 4-bromoantipyrine 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 74-88-4 methyl iodide 

Downstream Products

• 23097-55-4 methoxy-4 antipyrine 
• 100615-46-1 4-ethoxy-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 123777-28-6 4,4'-bis-benzyloxy-1,1'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-5,5'-ethanediyl-bis-pyrazol-3-one 
• 103032-43-5 4,4'-diacetoxy-1,1'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-5,5'-ethanediyl-bis-pyrazol-3-one 
• 76788-81-3 Bernsteinsaeure 
• 28070-40-8 4-Hydroxy-antipyrine β-D-glucuronide 
• 81416-56-0 4-Hydroxyantipyrine Sulfate 
• 76788-80-2 Bis(4,4'-hydroxyphenazon) 
• 38604-70-5 1-acetyl-1-methyl-2-phenylhydrazine 
• 144-62-7 oxalic acid 
• 38988-02-2 Oxalsaeure-mono(2-acetyl-2-methyl-1-phenyl)hydrazid 
• 620-81-5 N,N'-Diphenyloxamid 
• 10605-18-2 N-Methyl-N-phenyl oxamide 
• 88741-26-8 6-Methyl-2-<1-(methylimino)ethyl>-4-oxohepta-2,5-dienoic anilide 

Related news

Assay of antipyrine and its main metabolites 3-hydroxymethylantipyrine, norantipyrine and 4-HYDROXYANTIPYRINE (cas 1672-63-5) in urine☆09/25/2019

Two assay methods for antipyrine (AP) and its main metabolites 3-hydroxymethylantipyrine (3-HMA), norantipyrine (NORA) and 4-hydroxyantipyrine (4-HA) in urine samples have been compared. Method I involved a 3 h incubation at 37°C with β-glucuronidase, whereas method II used acid hydrolysis wit...detailed

Separation and identification of the 4-HYDROXYANTIPYRINE (cas 1672-63-5) sulphoconjugate09/24/2019

In a previous study we observed, during separation of total antipyrine metabolites by high-performance liquid chromatography and after enzymatic hydrolysis, an unidentified peak corresponding to an ionic compound with pyrazolinone features. In the present study, this compound was identified as t...detailed

Relevant articles and documents

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Photochemical decomposition of phenazone derivatives. Part 7: Mechanism of decomposition in aqueous solutions

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Stability of phenazone

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