16778-21-5 Usage
Description
4-Chloro-8-methoxyquinoline is a chemical compound characterized by its yellow solid appearance. It is a derivative of quinoline, a nitrogen-containing aromatic compound, with a chlorine atom at the 4th position and a methoxy group at the 8th position.
Uses
Used in Pharmaceutical Industry:
4-Chloro-8-methoxyquinoline is used as a potent selective CRTh2 (DP2) antagonist for the potential treatment of asthma, allergic rhinitis, and other inflammatory diseases. Its antagonistic properties make it a valuable compound in the development of medications targeting these conditions.
Used in Chemical Research:
As a quinoline derivative, 4-Chloro-8-methoxyquinoline may also be utilized in chemical research and development for the synthesis of other compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 16778-21-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,7 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 16778-21:
(7*1)+(6*6)+(5*7)+(4*7)+(3*8)+(2*2)+(1*1)=135
135 % 10 = 5
So 16778-21-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H8ClNO/c1-13-9-4-2-3-7-8(11)5-6-12-10(7)9/h2-6H,1H3
16778-21-5Relevant articles and documents
INHIBITORS FOR THE TREATMENT OF CANCER AND RELATED METHODS
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Paragraph 0032; 0176, (2019/05/15)
Some embodiments of the invention include inventive compounds. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutica
SELECTIVE PFKFB4 INHIBITORS FOR THE TREATMENT OF CANCER
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Page/Page column 61, (2016/11/14)
Methods and pharmaceutical compositions for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and the treatment of cancer are described.
Improved Syntheses of Some Monohloro- and Monobromo-8-quinolinols
Gershon, Herman,Clarke, Donald D.
, p. 935 - 942 (2007/10/02)
Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz 1H-NMR spetra for the 12 possible monochloro