28027-18-1 Usage
General Description
4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid, also known as oxolinic acid, is a synthetic quinolone antibiotic that is used to treat various bacterial infections. It works by inhibiting the bacterial DNA gyrase enzyme, which is responsible for the replication and repair of bacterial DNA. This drug is effective against a wide range of gram-negative and some gram-positive bacteria. It is commonly used in the treatment of urinary tract infections, respiratory tract infections, and skin and soft tissue infections. Overall, 4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid is a potent and versatile antibiotic with a broad spectrum of action.
Check Digit Verification of cas no
The CAS Registry Mumber 28027-18-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,0,2 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 28027-18:
(7*2)+(6*8)+(5*0)+(4*2)+(3*7)+(2*1)+(1*8)=101
101 % 10 = 1
So 28027-18-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H9NO4/c1-16-8-4-2-3-6-9(8)12-5-7(10(6)13)11(14)15/h2-5H,1H3,(H,12,13)(H,14,15)
28027-18-1Relevant articles and documents
Synthesis and anti-tumor activities of 4-anilinoquinoline derivatives
Liu, Dan,Luan, Tian,Kong, Jian,Zhang, Ying,Wang, Hai-Feng
, (2016/02/05)
Twenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a-g; 2c; 2e and 2i) exhibited excellent antitumor activity superior to that of gefitinib. Among the ten compounds; seven (1a-c; 1e-1g and 2i) displayed excellent selectivity for BGC823 cells. In particular; 1f and 2i exhibited potent cytotoxic activities against HeLa cells and BGC823 cells with better IC50 values than gefitinib.
