16837-52-8 Usage
Description
Ammothamnine is an alkaloid derived from the plant Sophora angustifolia var. flavescens S. and Z. It crystallizes as a monohydrate with a specific melting point and exhibits dextrorotatory optical activity. The compound has been found to have various biological activities, including anti-tumor, antiviral, and anti-inflammatory properties, making it a potential candidate for pharmaceutical applications.
Uses
Used in Anticancer Applications:
Ammothamnine is used as an anti-tumor agent for triggering apoptosis in human leukemia cells. It modulates oncological signaling pathways and demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Antifungal Applications:
Ammothamnine is used as an antifungal agent, exhibiting activity against various fungal pathogens.
Used in Hepatoprotectant Applications:
Ammothamnine is used as a hepatoprotectant, preventing fibrosis in the liver and other organs, at least in part by interfering with TGF-β signaling.
Used in Antiviral Applications:
Ammothamnine is used as an antiviral agent, particularly for inhibiting the replication of hepatitis B, both alone and in combination with lamivudine.
Used in Anti-Inflammatory Applications:
Ammothamnine is used as an anti-inflammatory agent, ameliorating inflammation by impairing the translocation of nuclear factors-κB.
References
Kondo et al., Arch. Pharm., 275,493 (1937)
Ochiai, Ito., Ber., 81,938 (1938)
Check Digit Verification of cas no
The CAS Registry Mumber 16837-52-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,3 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 16837-52:
(7*1)+(6*6)+(5*8)+(4*3)+(3*7)+(2*5)+(1*2)=128
128 % 10 = 8
So 16837-52-8 is a valid CAS Registry Number.
InChI:InChI=1/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
