16874-06-9Relevant articles and documents
Radiosynthesis of novel N-18F-labeled 18F-FHex-α-l-Glu and 18F-FHex-β-Glu
Wen, Fuhua,Liu, Shaoyu,Ma, Hui,Tang, Ganghua
, p. 222 - 230 (2020/04/02)
N-18F-labeled amino acids are important substitutes for new positron emission tomography (PET) imaging tracers complementing the deficiency of 18F-fluorodeoxyglucose (18F-FDG). In this work, two novel N-6-18F-alkyl amino acid imaging agents, 18F-FHex-α-l-Glu and 18F-FHex-β-Glu, were designed and synthesized as potential probes for PET imaging of tumors. 18F-FHex-α-l-Glu was synthesized using the precursor 6 from 18F-F? with the yield of 16 ± 4% (n = 5, uncorrected) within about 50 minutes. The specific activity was 14.5 GBq/μmol, and the radiochemical purity was more than 95%. 18F-FHex-β-Glu was synthesized using the precursor 12 based on 18F-F? with the yield of 11 ± 3% (n = 3, uncorrected) in about 60 minutes. The specific activity was 9.1 GBq/μmol, and the radiochemical purity was more than 95%.
Asymmetric Synthesis of α-Amino Acids by Organocatalytic Biomimetic Transamination
Kang, Qi-Kai,Selvakumar, Sermadurai,Maruoka, Keiji
supporting information, p. 2294 - 2297 (2019/04/10)
A biomimetic enantioselective transamination of α-keto ester derivatives can be realized under mild conditions by using chiral quaternary ammonium arenecarboxylates in the absence of base additives. The corresponding α-amino acids can be used as versatile intermediates for further synthetic transformations that furnish chiral pyrrolidine and octahydroindolizine derivatives.
A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters
Eastwood, Amy L.,Blum, Angela P.,Zacharias, Niki M.,Dougherty, Dennis A.
supporting information; experimental part, p. 9241 - 9244 (2010/03/01)
(Chemical Equation Presented) A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry