2419-56-9

Basic information

• Product Name: L-Glutamic acid 5-tert-butyl ester
• Synonyms: L-Glutamic acid 5-te;Glu(OtBu);H-L-Glu(OtBu)-OH;(2S)-2-Amino-5-tert-butoxy-5-oxopentanoic acid;H-Glu(OtBu)-OH·H2O L-GlutaMic acid γ-tert·butyl ester Monohydrate;5-tert-Butyl L-GlutaMate;5-tert-Butyl L-GlutaMate Hydrate;(S)-2-aMino-5-(tert-butoxy)-5-oxopentanoic acid
• CAS NO: 2419-56-9
• Molecular Formula: C₉H₁₇NO₄
• Molecular Weight: 203.24
• EINECS: 247-005-6
• Product Categories: Amino Acids;Glutamic acid [Glu, E];Amino Acids and Derivatives;Amino Acid Derivatives;Glutamic Acid;Peptide Synthesis
• Mol File: 2419-56-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 182°C(lit.)
• Boiling Point: 336.4 °C at 760 mmHg
• Flash Point: 157.3 °C
• Appearance: /Solid
• Density: 1.133 g/cm³
• Vapor Pressure: 2.11E-05mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: 2-8°C
• PKA: 2.20±0.10(Predicted)
• Water Solubility: Sparingly soluble in water; practically insoluble in ethanol or ether.
• BRN: 2049031
• CAS DataBase Reference: L-Glutamic acid 5-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid 5-tert-butyl ester(2419-56-9)
• EPA Substance Registry System: L-Glutamic acid 5-tert-butyl ester(2419-56-9)

Safety Data

• Statements: 22-24
• Safety Statements: 22-24/25-25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2419-56-9(Hazardous Substances Data)

Usage

Description

L-Glutamic acid 5-tert-butyl ester is a white powder crystal that serves as a crucial intermediate in the synthesis of various compounds, particularly in the pharmaceutical and fine chemical industries. Its unique chemical structure allows it to be a versatile building block for the development of new drugs and other specialty chemicals.

Uses

Used in Pharmaceutical Industry:
L-Glutamic acid 5-tert-butyl ester is used as a pharmaceutical intermediate for the development of new drugs. Its role in this industry is to provide a stable and functional building block that can be further modified or combined with other molecules to create therapeutically active compounds.
Used in Fine Chemical Industry:
In the fine chemical industry, L-Glutamic acid 5-tert-butyl ester is utilized as a fine chemical intermediate. It is employed in the synthesis of specialty chemicals that have specific applications in various fields, such as agriculture, materials science, and environmental science. Its versatility and stability make it a valuable component in the development of these advanced materials and compounds.

InChI:InChI=1/C9H17NO4/c1-9(2,3)14-7(11)5-4-6(10)8(12)13/h6H,4-5,10H2,1-3H3,(H,12,13)/t6-/m0/s1

Upstream product

• 3886-08-6 5-tert-butyl N-benzyloxycarbonyl-L-glutamate 
• 62188-74-3 H-Glu(O-t-Bu)-OBzl 
• 56-86-0 L-glutamic acid 
• 115-11-7 isobutene 
• 16874-06-9 di-tert-butyl L-glutamate 
• 71989-18-9 Fmoc-Glu(OtBu)-OH 
• 32677-01-3 L-glutamic acid di-tert-butyl ester hydrochloride 
• 56877-41-9 methyl 2(S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonylbutanoate 
• 3705-42-8 Cbz-(L)-Glu-OBn 
• 3967-18-8 (S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-benzyl ester 5-tert-butyl ester 
• 47709-87-5 N-(2-)-propyl-(2)-oxycarbonyl)-glutaminsaeure-γ-tert.-butylester 
• 13030-09-6 1-benzyl L-glutamate 

Downstream Products

• 1264272-63-0 5-(tert-butoxy)-2-(4-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzamido)-5-oxopentanoic acid 
• 86409-29-2 γ-tert-butyl-l-glutamic acid N-carboxyanhydride 

Relevant articles and documents

Synthesis of ω-tert-butyl esters of aspartic acid and glutamic acid via B,B-difluoroboroxazolidones

B,B-Difluoroboroxazolidones (DFBONs) were synthesized for the first time from salts of amino acid and BF3·Et2O, and their properties were examined. DFBONs were used in selective preparation of Glu(OBu(t)) and Asp(OBu(t)) in good yields under catalysis with BF3·Et2O and H3PO4. Amberlite XAD-2 resin was successfully employed to purify the above amino acid derivatives.

ANTI-CD40 ANTIBODY DRUG CONJUGATES

Provided herein are anti-CD40 antibody drug conjugates comprising a radical of Formula (I), wherein R1, R2, and R3 are as defined herein. Further provided are anti-CD40 antibody drug conjugates of Formula (II), wherein Z, R, AA1, AA2, AA3, m, p, q, n, w, R1, R2, and R3 are as defined herein. Further provided are pharmaceutical compositions and kits thereof, and methods of using same.

Fluorescent mimics of cholesterol that rapidly bind surfaces of living mammalian cells

Mammalian cells acquire cholesterol, a critical membrane constituent, through multiple mechanisms. We synthesized mimics of cholesterol, fluorescent N-alkyl-3β-cholesterylamine-glutamic acids, that are rapidly incorporated into cellular plasma membranes compared with analogous cholesteryl amides, ethers, esters, carbamates, and a sitosterol analogue. This process was inhibited by ezetimibe, indicating a receptor-mediated uptake pathway.