1692-02-0

Basic information

• Product Name: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE
• Synonyms: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE;N-(4-Fluorobenzyl)pyridin-2-aMine dihydrochloride
• CAS NO: 1692-02-0
• Molecular Formula: C₁₂H₁₁FN₂
• Molecular Weight: 275.1494232
• Mol File: 1692-02-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 326.6±22.0 °C(Predicted)
• Appearance: /
• Density: 1.210±0.06 g/cm3(Predicted)
• PKA: 6.21±0.10(Predicted)
• CAS DataBase Reference: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE(1692-02-0)
• EPA Substance Registry System: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE(1692-02-0)

Safety Data

• Hazardous Substances Data: 1692-02-0(Hazardous Substances Data)

Usage

Description

(4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE is a chemical compound that features a pyridine ring connected to a (4-fluoro-benzyl) group. (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE is widely utilized in organic synthesis and medicinal chemistry as a key building block for the development of pharmaceuticals and biologically active molecules. The dihydrochloride salt form enhances the compound's stability and ease of handling in laboratory settings. Its capacity to alter the structure and function of biomolecules renders it valuable for drug discovery and development, with a particular focus on neurological disorders and infectious diseases. Furthermore, it serves as a reagent in chemical reactions to introduce the (4-fluoro-benzyl) and pyridin-2-yl-amine groups into molecules for additional functionalization.

Uses

Used in Pharmaceutical Industry:
(4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE is used as a building block for the development of various pharmaceuticals and biologically active molecules, particularly targeting neurological disorders and infectious diseases. Its unique structure allows for the creation of compounds with potential therapeutic effects against these conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE is employed as a reagent to introduce the (4-fluoro-benzyl) and pyridin-2-yl-amine groups into molecules. This functionalization can lead to the discovery of new drugs with improved pharmacological properties and enhanced efficacy.
Used in Organic Synthesis:
(4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE is also used in organic synthesis as a versatile building block. Its incorporation into various molecular structures can result in the creation of novel compounds with diverse applications, including potential uses in materials science, agrochemicals, and other specialty chemical industries.

Upstream product

• 504-29-0 2-aminopyridine 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 459-56-3 4-fluorobenzylic alcohol 
• 459-57-4 4-fluorobenzaldehyde 
• 462-08-8 pyridin-3-ylamine 
• 372-48-5 2-fluoropyridine 
• 140-75-0 para-fluorobenzylamine 
• 104-87-0 4-methyl-benzaldehyde 
• 1445435-43-7 C₁₇H₁₉FN₂O₂ 

Downstream Products

• 136343-75-4 8-fluoropyrido[1,2-a]benzimidazole 
• 1039803-54-7 (5-bromo-pyridin-2-yl)-(4-fluoro-benzyl)-amine 
• 396-59-8 N-(4-fluoro-benzyl)-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine 

Relevant articles and documents

Isoxazole-containing pyridopyrimidinone compound as well as preparation method and application thereof

The invention relates to an isoxazole-containing pyridinopyrimidinone compound as well as a preparation method and application thereof. The compound disclosed by the invention has a structure shown as a formula (I), has excellent insecticidal activity on sogatella furcifera, brown planthopper and the like, and can be used for medicines or agents for preventing and treating hemiptera pests such as rice planthoppers and aphids. The structure and the preparation process are simple, and the production cost is low.

Co(II) PCP Pincer Complexes as Catalysts for the Alkylation of Aromatic Amines with Primary Alcohols

Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N′-bis(diisopropylphosphino)-N,N′-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold. This reaction is an environmentally benign process implementing inexpensive, earth-abundant nonprecious metal catalysts and is based on the acceptorless alcohol dehydrogenation concept. A range of primary alcohols and aromatic amines were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields.

A mild method for the regioselective bromination of 2-aminopyridines

An efficient and regioselective bromination of 2-aminopyridines was developed. The environmental friendly bromination occurs under mild and clean conditions using readily available 1-butylpyridinium bromide as the bromine source and hydrogen peroxide as the green oxidant.