169944-04-1

Basic information

• Product Name: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE
• Synonyms: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE;4-PHENOXYBENZYLAMINE HCL;(4-Phenoxyphenyl)MethanaMine hydrochloride;(4-Phenoxyphenyl)
• CAS NO: 169944-04-1
• Molecular Formula: C13H14ClNO
• Molecular Weight: 235.70936
• Mol File: 169944-04-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 351.7°C at 760 mmHg
• Flash Point: 166.5°C
• Appearance: /
• Vapor Pressure: 2.84E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE(169944-04-1)
• EPA Substance Registry System: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE(169944-04-1)

Safety Data

• Hazardous Substances Data: 169944-04-1(Hazardous Substances Data)

Usage

General Description

"(4-Phenoxyphenyl)methylamine Hydrochloride" is a chemical compound that is typically used in research and development fields, and it's generally used as an intermediate in organic synthesis. The compound is a type of amine, a basic nitrogenous compound, where one of its aromatic rings is substituted with a phenoxy group. The presence of the hydrochloride indicates that it's a salt variant, which enhances its solubility in water. As with many such compounds, its usage requires appropriate safety measures due to its potential to cause skin or eye irritation, respiratory irritation, and other health hazards upon exposure. Detailed information about specific handling procedures and potential hazards should be provided in its Safety Data Sheet (SDS).

InChI:InChI=1/C13H13NO.ClH/c14-10-11-6-8-13(9-7-11)15-12-4-2-1-3-5-12;/h1-9H,10,14H2;1H

Upstream product

• 3096-81-9 4-phenoxybenzonitrile 
• 67-36-7 4-phenoxy benzaldehyde 

Relevant articles and documents

Bicyclic (alkyl)(amino)carbene (BICAAC) as a metal-free catalyst for reduction of nitriles to amines

Bicyclic (alkyl)(amino)carbene (BICAAC) is introduced as a metal-free catalyst for the reduction of various nitriles to the corresponding amine hydrochloride salts in the presence of pinacolborane. Mechanistic investigations combining experiments and DFT calculations suggest a B-H addition to the carbene center, which acts as a carrier of the hydride source. This journal is

HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS

The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Boron-Catalyzed Silylative Reduction of Nitriles in Accessing Primary Amines and Imines

Silylative reduction of nitriles was studied under transition metal-free conditions by using B(C6F5)3 as a catalyst with hydrosilanes as a reductant. Alkyl and (hetero)aryl nitriles were efficiently converted to primary amines or imines under mild conditions. The choice of silanes was found to determine the selectivity: while a full reduction of nitriles was highly facile, the use of sterically bulky silanes allowed for the partial reduction leading to N-silylimines.