169957-63-5

Basic information

• Product Name: (1S,5R,6S)-2-[7-[4-(Carbamoylmethyl)-1,4-diazabicyclo[2.2.2]octane-1,4-diylium-1-ylmethyl]-9-oxofluoren-3-yl]-6-[1(R)-hydroxyethyl]-1-methyl-1-carba-2-penem-3-carboxylate chloride
• Synonyms: L-742728
• CAS NO: 169957-63-5
• Molecular Formula: C₃₂H₃₅ClN₄O₆
• Molecular Weight: 607.11195
• Mol File: 169957-63-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,5R,6S)-2-[7-[4-(Carbamoylmethyl)-1,4-diazabicyclo[2.2.2]octane-1,4-diylium-1-ylmethyl]-9-oxofluoren-3-yl]-6-[1(R)-hydroxyethyl]-1-methyl-1-carba-2-penem-3-carboxylate chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,5R,6S)-2-[7-[4-(Carbamoylmethyl)-1,4-diazabicyclo[2.2.2]octane-1,4-diylium-1-ylmethyl]-9-oxofluoren-3-yl]-6-[1(R)-hydroxyethyl]-1-methyl-1-carba-2-penem-3-carboxylate chloride(169957-63-5)
• EPA Substance Registry System: (1S,5R,6S)-2-[7-[4-(Carbamoylmethyl)-1,4-diazabicyclo[2.2.2]octane-1,4-diylium-1-ylmethyl]-9-oxofluoren-3-yl]-6-[1(R)-hydroxyethyl]-1-methyl-1-carba-2-penem-3-carboxylate chloride(169957-63-5)

Safety Data

• Hazardous Substances Data: 169957-63-5(Hazardous Substances Data)

Upstream product

• 186817-91-4 (4R,5R,6S)-4-methyl-3,7-dioxo-6-((1'R)-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl-ester 
• 212691-51-5 6-bromo-9,9-dimethoxy-2-methyl-9H-fluorene 
• 165817-82-3 4-nitrobenzyl (1R,5R,6S)-1-methyl-6-[(1R)-triethylsilanyloxy-ethyl]-2-(trifluoro-methanesulfonyloxy)-carbapen-2-em-3-carboxylate 
• 154428-43-0 (4R,5R,6S)-6-((R)-1-Hydroxy-ethyl)-4-methyl-7-oxo-3-trifluoromethanesulfonyloxy-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 137154-53-1 3-bromo-7-methyl-9-fluorenone 
• 91713-57-4 (2-amino-5-methylphenyl)(4-bromophenyl)methanone 
• 90822-24-5 (γR,2R,3S)-α-diazo-3-[(1R)-1-hydroxyethyl]-γ-methyl-β,4-dioxo-2-azetidinebutanoic acid (4-nitrophenyl)methyl ester 
• 104873-15-6 4-nitrobenzyl (4R,5R,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]-heptane-2-carboxylate 
• 106-49-0 p-toluidine 
• 623-00-7 4-bromobenzenecarbonitrile 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 186817-88-9 (R)-2-Diazo-3-oxo-4-[(2R,3S)-4-oxo-3-((R)-1-triethylsilanyloxy-ethyl)-azetidin-2-yl]-pentanoic acid 4-nitro-benzyl ester 

Relevant articles and documents

Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties

The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl substituent was found to improve pharmacokinetics.