104873-15-6Relevant articles and documents
Synthesis, crystal structures and catalytic activity of tetrakis(acetato)dirhodium(II) complexes with axial picoline ligands
Ye, Qing-Song,Li, Xiao-Nian,Jin, Yi,Yu, Juan,Chang, Qiao-Wen,Jiang, Jing,Yan, Cai-Xian,Li, Jie,Liu, Wei-Ping
, p. 113 - 120 (2015)
Three complexes were synthesized in high yields by reaction of Rh2(O2CCH3)4 with 2-picoline (1), 3-picoline (2) and 4-picoline (3), respectively, and characterized by elemental analysis, ESI+-MS, FT-I
AN IMPROVED PROCESS FOR THE PREPARATION OF MEROPENEM
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Page/Page column 10-12, (2011/12/02)
The present invention provides an improved process for the preparation of methyl carbapenem derivative of formula (I) or its pharmaceutically acceptable salts or hydrates thereof in a pure form.
IMPROVED METHOD FOR THE CRYSTALLIZATION OF INTERMEDIATES OF CARBAPENEM ANTIBIOTICS
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Page/Page column 10, (2009/01/24)
The present invention relates to an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds. The present invention provides a crystallization method to obtain a crystal which has a higher quality and a higher stability than a conventional crystal and is excellent in filterability at the time of recovering crystal; an azetidinone compound having a low content of impurity; and an azetidinone compound which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound. According to the method, the crystal having a high quality and a high stability and excellent filterability at the time of recovering the crystal can be obtained.