170019-22-4Relevant articles and documents
Controlled mono- and double-Heck reaction catalyzed by a dicarbene dipalladium complex
Li, Yunfei,Liu, Gang,Cao, Changsheng,Wang, Shuzhan,Li, Yuling,Pang, Guangsheng,Shi, Yanhui
, p. 6241 - 6250 (2013/07/27)
The phosphine-free mono- and double-Heck reaction of terminal olefins with electron-deficient and electron-rich aryl halides (iodides and bromides) is described. These reactions are catalyzed by the dicarbene dipalladium complex 1 by controlling the stoichiometry of the aryl halide and the olefine, the loading of the palladium catalyst, as well as using different base, and with or without additive. The procedure of double-Heck reaction allows β,β- diarylation and β,β′-diarylation of terminal olefins and affords trisubstituted olefins in good to excellent yields.
Palladium-catalyzed double arylations of terminal olefins in acetic acid
Xu, Daichao,Lu, Chunxin,Chen, Wanzhi
experimental part, p. 1466 - 1474 (2012/03/08)
A palladium-catalyzed Heck diarylation of terminal olefins under ligand-free conditions in acetic acid is described. This procedure allows double arylation of terminal olefins affording trisubstituted olefins in good to excellent yields. The methodology is applicable to the coupling of both electron-deficient and electron-rich aryl iodides leading to symmetrical and unsymmetrical β,β-diarylated alkenes.
Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
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, (2008/06/13)
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cogniti
