170171-53-6

Basic information

• Product Name: 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
• Synonyms: 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
• CAS NO: 170171-53-6
• Molecular Weight: 983.291
• Mol File: 170171-53-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel(170171-53-6)
• EPA Substance Registry System: 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel(170171-53-6)

Safety Data

• Hazardous Substances Data: 170171-53-6(Hazardous Substances Data)

Upstream product

• 114915-20-7 Docetaxel 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 

Relevant articles and documents

Relationships between the structure of taxol analogues and their antimitotic activity

A variety of synthetic analogues of taxol, a naturally occurring antitumor diterpene, were examined for their potency to inhibit microtubule disassembly. For some of the compounds, the in vitro cytotoxic properties showed a good correlation with the tubulin assay. This structure-activity relationship study shows that inhibition of microtubule disassembly is quite sensitive to the configuration at C-2' and C-3'. A correlation between the conformation of the side chain at C-13 and the activity is suggested. Of all the compounds examined, one of the most potent in inhibiting microtubule disassembly and in inhibiting murine P388 leukemic cells, N-debenzoyl-N-tert-(butoxycarbonyl)-10-deacetyltaxol, named taxotere, was selected for evaluation as a potential anticancer agent.