170438-03-6Relevant articles and documents
A practical synthesis of enantiopure (S)-4-(4-hydroxybenzyl)-oxazolidin-2-one
Green, Rachel,Taylor, Piers J. M.,Bull, Steven D.,James, Tony D.,Mahon, Mary F.,Merritt, Andy T.
, p. 2619 - 2623 (2003)
A high yielding four-step synthesis of enantiopure 4-(4-hydroxybenzyl)-oxazolidin-2-one (S)-1 from N-Boc-L-tyrosine is described. (S)-1 is a key intermediate for the preparation of a number of polymer supported Evans' oxazolidin-2-ones that have been employed previously for solid supported asymmetric synthesis.
Rhodium-catalyzed borylation of aryl 2-pyridyl ethers through cleavage of the carbon-oxygen bond: Borylative removal of the directing group
Kinuta, Hirotaka,Tobisu, Mamoru,Chatani, Naoto
supporting information, p. 1593 - 1600 (2015/03/05)
The rhodium-catalyzed reaction of aryl 2-pyridyl ethers with a diboron reagent results in the formation of arylboronic acid derivatives via activation of the C(aryl)-O bonds. The straightforward synthesis of 1,2-disubstituted arenes was enabled through catalytic ortho C-H bond functionalization directed by the 2-pyridyloxy group followed by substitution of this group with a boryl group. Several control experiments revealed that the presence of a sp2 nitrogen atom at the 2-position of the substrate and the use of a boron-based reagent were crucial for the activation of the relatively inert C(aryl)-O bond of aryl 2-pyridyl ethers.
Synthesis of chiral α-substituted β-hydroxy acid derivatives on solid support
Purandare, Ashok V.,Natarajan, Sesha
, p. 8777 - 8780 (2007/10/03)
Enantioselective aldol condensation using solid supported chiral auxiliary was used for the synthesis of α-substituted-β-hydroxy acid and ester. The solid phase synthesis proceeded with high degree of enatioselectivity, as is observed in solution chemistry.
