187521-90-0Relevant articles and documents
An Improved Preparation of Oxazolidin-2-one Chiral Auxiliaries
Sudharshan, Manjula,Hultin, Philip G.
, p. 171 - 172 (1997)
Reduction of carbamate-blocked amino esters by lithium borohydride (made in situ from sodium borohydride and lithium iodide) forms chiral 4-substituted oxazolidin-2-ones directly. The presence of iodide in the reaction mixture appears to promote the cyclization of the intermediate alkoxyborohydride. This provides a route to these important chiral auxiliaries, employing less hazardous reagents and simpler reaction conditions than do most existing methods.
