17061-61-9

Basic information

• Product Name: 4-METHOXYBENZYLAMINE HYDROCHLORIDE
• Synonyms: 4-METHOXYBENZYLAMINE HYDROCHLORIDE;BenzeneMethanaMine, 4-Methoxy- (hydrochloride)(1:1);[[4-Methoxyphenyl]methyl]amine hydrochloride;(4-methoxyphenyl)methanamine hydrochloride
• CAS NO: 17061-61-9
• Molecular Formula: C₈H₁₁NO*ClH
• Molecular Weight: 173.63998
• Mol File: 17061-61-9.mol
• Article Data: 50

Chemical Properties

• Melting Point: 243-244℃
• Boiling Point: 236.5°Cat760mmHg
• Flash Point: 98.8°C
• Appearance: /
• Density: 1.028g/cm³
• CAS DataBase Reference: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(17061-61-9)
• EPA Substance Registry System: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(17061-61-9)

Safety Data

• Hazardous Substances Data: 17061-61-9(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzylamine hydrochloride is a chemical compound derived from benzylamine, which is commonly used in organic synthesis. It is a white solid with a molecular formula of C8H11NO and a molecular weight of 137.18 g/mol. 4-METHOXYBENZYLAMINE HYDROCHLORIDE is often utilized as a reagent in the preparation of various pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of dyes and pigments. 4-Methoxybenzylamine hydrochloride is known for its role as an intermediate in the production of a wide range of organic compounds and has applications in various industries.

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 29559-26-0 (p-methoxyphenyl)nitromethane 
• 3424-93-9 4-methoxyphenylacetamide 
• 1258944-85-2 MeO(C₆H₄)CH₂N(SiMe₂Ph)2 
• 2393-23-9 4-methoxy-benzylamine 
• 767-00-0 4-cyanophenol 
• 874-90-8 4-methoxybenzonitrile 
• 77-78-1 dimethyl sulfate 
• 6343-93-7 2-(4-methoxyphenyl)acetamide 
• 1849-02-1 2-chloro-1-methyl-benzimidazole 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 54582-35-3 p-methoxybenzylurea 
• 1053417-19-8 diethyl 1,4-dihydro-1-(4-methoxybenzyl)-4-phenyl-pyridine-3,5-dicarboxylate 
• 83301-14-8 diethyl 4-(4-methoxylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 667416-44-6 diethyl 1-(4-methoxyphenymethyl)-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 38164-13-5 1-(4-methoxy-benzyl)-biguanide 
• 1381874-49-2 4-(4-methoxybenzylamino)-2,8-dimethyl-6H-pyrimido[1,2-a]-[1,3,5]triazin-6-one 
• 907972-03-6 C₁₄H₁₇N₅O₂ 
• 4767-41-3 N₁-(4-methoxy)benzyl biguanide hydrochloride 
• 1333500-36-9 4,6-diamino-2-ethyl-2-methyl-1,2-dihydro-1-(4'-methoxybenzyl)-1,3,5-triazine hydrochloride 
• 1333500-44-9 C₁₆H₂₃N₅O*ClH 

Relevant articles and documents

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Silver-Catalyzed Hydroboration of C-X (X = C, O, N) Multiple Bonds

AgSbF6 was developed as an effective catalyst for the hydroboration of various unsaturated functionalities (nitriles, alkenes, and aldehydes). This atom-economic chemoselective protocol works effectively under low catalyst loading, base- A nd solvent-free moderate conditions. Importantly, this process shows excellent functional group tolerance and compatibility with structurally and electronically diverse substrates (>50 examples). Mechanistic investigations revealed that the reaction proceeds via a radical pathway. Further, the obtained N,N-diborylamines were showcased to be useful precursors for amide synthesis.

Green method for catalyzing reduction reaction of aliphatic nitro derivative

The invention relates to a green method for catalyzing reduction reaction of aliphatic nitro derivatives. According to the method, non-transition metal compounds, namely triethyl boron and potassium tert-butoxide, are used as a catalytic system for the first time, an aliphatic nitro derivative and pinacolborane which is low in price and easy to obtain are catalyzed to be subjected to a reduction reaction under mild conditions, and an aliphatic amine hydrochloride product is synthesized after acidification with a hydrochloric acid aqueous solution. Compared with a traditional method, the method generally has the advantages that the catalyst is cheap and easy to obtain, operation is convenient, and reaction is safe. The selective reduction reaction of the aliphatic nitro derivative catalyzed by the non-transition metal catalyst and pinacol borane is realized for the first time, and the aliphatic amine hydrochloride product is synthesized through acidification treatment of the hydrochloric acid aqueous solution, so that a practical new reaction strategy is provided for laboratory preparation or industrial production.