3424-93-9Relevant articles and documents
The Acid-Catalyzed and Uncatalyzed Hydrolysis of Nitriles on Unactivated Alumina
Wilgus, Catherine Pala,Downing, Susan,Molitor, Erich,Bains, Satinder,Pagni, Richard M.,Kabalka, George W.
, p. 3469 - 3472 (1995)
Nitriles are selectively converted into amides on unactivated alumina, with the surface hydroxyl groups serving as the source of water.
A Mild Heteroatom (O -, N -, and S -) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH) 2Combination
Tang, Yu,Yu, Biao
, (2022/03/27)
A mild heteroatom methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2combination has been developed, which proceeds in DMF, or water, or under neat conditions, at 80 °C or at room temperature. A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, are suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol make it an attractive alternative to the conventional base-promoted heteroatom methylation procedures.
Method for preparing primary and secondary amide compounds
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Paragraph 0057-0067, (2021/02/06)
The invention belongs to the field of organic chemical synthesis, and particularly relates to a method for preparing primary and secondary amide compounds. The method for preparing primary and secondary amide compounds comprises the following steps of carrying out catalytic reduction on an N-substituted amide compound at 30-130 DEG C by using a protic solvent as a reduction reagent and a dichloro(p-methyl isopropylbenzene) ruthenium (II) dimer complex as a catalyst to obtain a reaction solution after the reduction reaction is finished, and carrying out post-treatment on the reaction solution to obtain the corresponding primary amide compound or secondary amide compound. According to the method for preparing the primary and secondary amide compounds, the transfer hydrogenation reaction of nitrogen-oxygen and nitrogen-carbon bonds is realized, the reaction conditions are mild and simple, the substrate application range is wide, the operation is convenient, and the corresponding primary amide compound or secondary amide compound is obtained with high efficiency and high selectivity.
Ruthenium(II) complexes bearing bidentate acylthiourea ligands for direct oxidation of amine α-carbon to amide
Aslan, Muhammed,Gumus, Ilkay
, (2021/10/07)
In this study, the synthesis and structural characterization of ruthenium complexes supported by S,O-acylthiourea ligands (L1-L6) with different substituent groups as well as auxiliary ligands PPH3, CO, and Cl and their evaluation as catalysts for direct oxidation of the α-methylene group in amines were reported. Ru(II) complexes, Ru1-Ru6, were prepared from the reaction of the RuH(CO)Cl(PPh3)3 precursor and ligands L1-L6 having different electronic and steric properties. The ligands and complexes prepared were characterized by FT-IR, 1H–13C- and/or 31P NMR spectroscopic techniques. The molecular structures of Ru1 and Ru3 complexes with appropriate crystal quality were also confirmed by X-ray single crystal analysis. Solid-state structures of Ru1 and Ru3 revealed that the ruthenium center is surrounded by one carbonyl, one chloride, two PPh3 ligands, and the S,O-donor atoms from the acylthiourea ligand in bidentate monoanionic form. The catalytic activity of all complexes for the α-oxygenation reactions of primary benzylic amines to amides was investigated. Overall, all catalysts exhibited excellent activity and selectivity towards the formation of amide production under the present reaction conditions. In addition, both catalyst activation and product selectivity/formation were particularly dependent on the amount/type of base and oxygen.