2362-64-3

Basic information

• Product Name: 4-METHOXYTHIOBENZAMIDE
• Synonyms: Benzenecarbothioamide,4-methoxy-;p-Anisamide,thio-;p-Methoxybenzothiamide;p-Methoxythiobenzamide;OTAVA-BB BB7020331318;4-METHOXYBENZOTHIOAMIDE;4-METHOXYBENZENE-1-CARBOTHIOAMIDE;4-METHOXYBENZENECARBOTHIOAMIDE
• CAS NO: 2362-64-3
• Molecular Formula: C₈H₉NOS
• Molecular Weight: 167.23
• Product Categories: Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds
• Mol File: 2362-64-3.mol
• Article Data: 57

Chemical Properties

• Melting Point: 145-149 °C(lit.)
• Boiling Point: 288.5 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: yellow powder
• Density: 1.194 g/cm³
• Vapor Pressure: 0.00233mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Refrigerator (+4°C)
• PKA: 13.02±0.29(Predicted)
• BRN: 1072444
• CAS DataBase Reference: 4-METHOXYTHIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYTHIOBENZAMIDE(2362-64-3)
• EPA Substance Registry System: 4-METHOXYTHIOBENZAMIDE(2362-64-3)

Safety Data

• Hazard Codes: Xi
• Statements: 43-20/22
• Safety Statements: 36-9
• RIDADR: 2811
• WGK Germany: 3
• PackingGroup: II
• Hazardous Substances Data: 2362-64-3(Hazardous Substances Data)

Usage

Description

4-Methoxythiobenzamide, a synthetic intermediate, is a yellow powder with potent hepatotoxic properties in vivo. It is primarily utilized in pharmaceutical synthesis, making it a valuable compound in the development of various medications.

Uses

Used in Pharmaceutical Synthesis:
4-Methoxythiobenzamide is used as a synthetic intermediate for the development of pharmaceuticals. Its unique chemical structure allows it to be a key component in the creation of various drugs, contributing to the advancement of medical treatments.
Used in Hepatotoxicity Research:
Due to its potent hepatotoxic nature, 4-Methoxythiobenzamide can be employed as a research tool in the study of liver toxicity. It can help scientists understand the mechanisms behind liver damage and develop strategies to mitigate or prevent such effects in the context of drug development and other applications.
Used in Chemical and Material Science:
As a yellow powder, 4-Methoxythiobenzamide may also find applications in the chemical and material science industries. Its distinctive color and properties could be harnessed for various purposes, such as in the development of pigments or other specialty chemicals.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2656, 1960 DOI: 10.1021/ja01495a078The Journal of Organic Chemistry, 41, p. 148, 1976 DOI: 10.1021/jo00863a035

InChI:InChI=1/C8H9NOS/c1-10-7-4-2-6(3-5-7)8(9)11/h2-5H,1H3,(H2,9,11)

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 62-55-5 thioacetamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 7047-13-4 5-p-methoxyphenyl-1,2,4-dithiazole-3-one 
• 45821-44-1 4-methoxy-benzylideneamine 
• 110-91-8 morpholine 
• 141-84-4 2-thioxo-4-thiazolidinone 
• 3424-93-9 4-methoxyphenylacetamide 
• 3717-21-3 p-methoxyl benzaldoxime 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 144-55-8 sodium hydrogencarbonate 
• 67-56-1 methanol 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 23421-57-0 4-chloromethyl-2-(4-methoxy-phenyl)-thiazole 
• 65823-55-4 2'-(4-methoxy-phenyl)-4-phenyl-[2,4']bithiazolyl 
• 56472-14-1 2-(4-methoxy-phenyl)-4-phenyl-6-p-tolyl-4H-[1,3,5]thiadiazine 
• 56472-12-9 2,6-bis-(4-methoxy-phenyl)-4-phenyl-4H-[1,3,5]thiadiazine 
• 126336-77-4 N-Azepan-(2E)-ylidene-4-methoxy-thiobenzamide 
• 114979-78-1 Dibutyl-(3-{4-[2-(4-methoxy-phenyl)-thiazol-4-yl]-phenoxy}-propyl)-amine 
• 25021-39-0 2-(4-methoxy-phenyl)-4-(4-nitro-phenyl)-thiazole 
• 25020-73-9 1,3-bis-{4-[2-(4-methoxy-phenyl)-thiazol-4-yl]-phenyl}-thiourea 
• 25179-44-6 1,3-bis-{4-[2-(4-methoxy-phenyl)-5-methyl-thiazol-4-yl]-phenyl}-thiourea 
• 91566-48-2 2-[2-(4-methoxy-phenyl)-thiazol-4-yl]-ethylamine 
• 100576-42-9 diethyl-{2-[2-(4-methoxy-phenyl)-thiazol-4-yl]-ethyl}-amine 
• 54883-29-3 4-[2-(4-methoxy-phenyl)-thiazol-4-yl]-aniline 
• 92292-49-4 {2-[2-(4-methoxy-phenyl)-thiazol-4-yl]-ethyl}-dimethyl-amine 
• 933772-61-3 4-difluoromethyl-2-(4-methoxy-phenyl)-thiazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine and synthesis method thereof

The invention belongs to the technical field of organic synthesis, and discloses 1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine and a chemical synthesis method thereof. The method comprises the following steps: by taking 4-methoxybenzoic acid as a raw material, carrying out acylation, substitution, sulfonylation, substitution, hydrolysis, substitution, substitution and reduction reaction to prepare 1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine. An efficient synthesis method is provided for synthesis of the compound.

Mo (CO)6-assisted Pd-supported magnetic graphene oxide-catalyzed carbonylation-cyclization as an efficient way for the synthesis of 4(3H)-quinazolinones

In this paper, a novel catalyst is introduced based on the immobilization of palladium on modified magnetic graphene oxide nanoparticles. The catalyst is characterized by several methods, including transmission electron microscopy, scanning electron microscopy, X-ray fluorescence, vibrating-sample magnetometer, Fourier transform-infrared and dynamic light scattering (DLS) analysis. The activity of the catalyst was investigated in the synthesis of 4(3H)-quinazolinones via Pd-catalyzed carbonylation-cyclization of N-(2-bromoaryl) benzimidamides by Mo (CO)6. The Mo (CO)6 is used as a carbon monoxide source for performing the reaction under mild conditions. The catalyst showed good reusability, and no change in activity was observed after 10?cycles of recovery.