7465-87-4

Basic information

• Product Name: BenzaMide, 4-Methoxy-N-(phenylMethyl)-
• Synonyms: BenzaMide, 4-Methoxy-N-(phenylMethyl)-
• CAS NO: 7465-87-4
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.2851
• Mol File: 7465-87-4.mol
• Article Data: 189

Chemical Properties

• Boiling Point: 441.2°Cat760mmHg
• Flash Point: 220.6°C
• Appearance: /Solid
• Density: 1.124g/cm³
• Vapor Pressure: 5.56E-08mmHg at 25°C
• Refractive Index: 1.576
• Water Solubility: Soluble in water.
• CAS DataBase Reference: BenzaMide, 4-Methoxy-N-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 4-Methoxy-N-(phenylMethyl)-(7465-87-4)
• EPA Substance Registry System: BenzaMide, 4-Methoxy-N-(phenylMethyl)-(7465-87-4)

Safety Data

• Hazardous Substances Data: 7465-87-4(Hazardous Substances Data)

Usage

General Description

Benzamide, 4-Methoxy-N-(phenylmethyl)- is a chemical compound with the molecular formula C15H15NO2. It is a member of the benzamide family, which are organic compounds containing the benzamide structure, consisting of a benzene ring with an amide group attached. This specific compound contains a 4-methoxy substituent and a phenylmethyl substituent. It is commonly used in organic synthesis and pharmaceutical research as a building block for creating other complex molecules. The compound has potential therapeutic applications as well, particularly in the development of new drugs for various medical conditions.

InChI:InChI=1/C15H15NO2/c1-18-14-9-7-13(8-10-14)15(17)16-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3,(H,16,17)

Upstream product

• 121-98-2 methyl 4-methoxybenzoate 
• 100-46-9 benzylamine 
• 94-30-4 ethyl 4-methoxybenzoate 
• 3532-17-0 4-methoxybenzoyl azide 
• 68055-31-2 N-benzyl-4-methoxybenzenecarbothioamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 874-90-8 4-methoxybenzonitrile 
• 100-51-6 benzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 696-62-8 para-iodoanisole 
• 29139-30-8 benzylaminepentacarbonylmolybdenum 
• 3287-99-8 benzylamine hydrochloride 
• 105-13-5 4-Methoxybenzyl alcohol 
• 15226-74-1 dicobalt octacarbonyl 

Downstream Products

• 3424-93-9 4-methoxyphenylacetamide 
• 619-57-8 p-hydroxybenzamide 
• 84570-80-9 2-(4-methoxylphenyl)-4-phenylquinazoline 
• 56463-47-9 1-benzyl-2-(4-methoxyphenyl)-1H-benzo[d]imidazole 
• 1609460-31-2 N-benzyl-4-methoxy-N′-phenylbenzimidamide 
• 588-46-5 N-(phenylmethyl)acetamide 
• 26209-45-0 N-benzyl-2,2-dimethylpropanamide 
• 14309-88-7 N-benzylthioacetamide 
• 103197-90-6 N-benzyl-2,2-dimethylpropanethioamide 
• 3027-02-9 N-acetyl-N-benzylacetamide 
• 1598437-64-9 N-acetyl-N-benzyl-4-methoxybenzamide 
• 65551-44-2 2-(N-benzylamino)-2-(4-methoxyphenyl)acetonitrile 
• 1028196-66-8 5-benzyl-9-methoxyphenanthridin-6(5H)-one 

Relevant articles and documents

TBAI-catalyzed C–N bond formation through oxidative coupling of benzyl bromides with amines: a new avenue to the synthesis of amides

A new green approach for the synthesis of amide through TBAI-catalyzed oxidative coupling of benzyl bromides with amine was developed in the presence of tert-butyl hydroperoxide (TBHP) as an oxidant. Various electron-donating and withdrawing groups containing benzyl bromides and various amines, were subjected to the reaction and transformed to the corresponding amide in good to excellent yields.

Br?nsted Acid Mediated Nucleophilic Functionalization of Amides through Stable Amide C?N Bond Cleavage; One-Step Synthesis of 2-Substituted Benzothiazoles

We have developed a Br?nsted acid mediated synthetic method to directly cleave stable amide C?N bonds by a variety of alcohol and amine nucleophiles. Reverse reactivity was observed and alcoholysis of amides by activated primary and secondary benzylic, and propargylic alcohols have been achieved instead of the expected nucleophilic substitution of alcohols. As an application, 2-substituted benzothiazole derivatives have been synthesized in one pot employing 2-aminothiophenol as nucleophile.

Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines

A straightforward method for the direct synthesis of amides from amines and carboxylic acids without exclusion of air or moisture using diphenylsilane with N-methylpyrrolidine has been developed. Various amides are made efficiently, and broad functional group compatibility is shown through a Glorius robustness study. A gram-scale synthesis demonstrates the scalability of this method. This journal is