171777-68-7

Basic information

• Product Name: N-(4-nitro<2,3,5,6-2H4>benzoyl)-L-glutamic acid diethyl ester
• CAS NO: 171777-68-7
• Molecular Weight: 356.312
• Mol File: 171777-68-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-nitro<2,3,5,6-2H4>benzoyl)-L-glutamic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-nitro<2,3,5,6-2H4>benzoyl)-L-glutamic acid diethyl ester(171777-68-7)
• EPA Substance Registry System: N-(4-nitro<2,3,5,6-2H4>benzoyl)-L-glutamic acid diethyl ester(171777-68-7)

Safety Data

• Hazardous Substances Data: 171777-68-7(Hazardous Substances Data)

Upstream product

• 171777-66-5 4-nitro<2,3,5,6-2H4>benzoic acid 
• 2037-26-5 ⁽²⁾H₈-toluene 

Downstream Products

• 171777-70-1 N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester-azomethin>-pterin 
• 171777-71-2 N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin 
• 171777-72-3 <2',3',5',6'-2H4>folic acid 
• 171777-69-8 N-(4-amino<2,3,5,6-2H4>benzoyl)-L-glutamic acid diethyl ester 

Relevant articles and documents

Preparation of [2',3',5',6'-2H4]pteroylglutamic acid

Folic acid plays a key role in nucleic acid biosynthesis, essential for normal cell proliferation and function. Localized folate deficiencies may be related to changes in cytology associated with cancer development; analogs of folic acid, such as methotrexate, are potent chemotherapeutic agents and are widely used either alone or in combination therapy for many types of cancer. In this report we describe the synthesis of a tetra-deuterated folic acid from perdeuterated toluene. The primary intermediate, N-(4-amino [2,3,5,6-2H4]benzoyl)-L-glutamic acid diethyl ester was coupled to N(2')-acetyl-6-formylpterin to create [2',3',5',6'-2H4]folic acid. A similar scheme can be used for the preparation of F [1',2',3',4',5',6'-13C6]folic acid from [13C6] ring labeled toluene.