17180-94-8

Basic information

• Product Name: 5-Chloropyrimidine
• Synonyms: 5-CHLOROPYRIMIDINE;Pyrimidine, 5-chloro- (6CI,8CI,9CI);PyriMidine, 5-chloro-;5-choloropyrimidine
• CAS NO: 17180-94-8
• Molecular Formula: C₄H₃ClN₂
• Molecular Weight: 114.53
• EINECS: 205-525-8
• Product Categories: PYRIMIDINE;APIs & Intermediate;Heterocycle-Pyrimidine series;alkyl chloride
• Mol File: 17180-94-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 36.5 °C
• Boiling Point: 172.956 °C at 760 mmHg
• Flash Point: 72.837 °C
• Appearance: /
• Density: 1.304 g/cm³
• Vapor Pressure: 1.733mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: 2-8°C
• PKA: 1.40±0.10(Predicted)
• CAS DataBase Reference: 5-Chloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloropyrimidine(17180-94-8)
• EPA Substance Registry System: 5-Chloropyrimidine(17180-94-8)

Safety Data

• Hazardous Substances Data: 17180-94-8(Hazardous Substances Data)

Usage

General Description

5-Chloropyrimidine is a chemical compound with the molecular formula C4H3ClN2. It is a chlorinated derivative of pyrimidine, which is a heterocyclic compound commonly found in DNA and RNA. 5-Chloropyrimidine is primarily used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes, pigments, and other organic compounds. It is a colorless to pale yellow liquid with a strong, pungent odor, and it is classified as a hazardous substance due to its irritating and corrosive properties. The compound is also known to be toxic to aquatic organisms, making it important to handle and dispose of it carefully. Overall, 5-Chloropyrimidine plays a crucial role in the chemical and pharmaceutical industries, but its use requires careful consideration of its potential risks and hazards.

InChI:InChI=1/C4H3ClN2/c5-4-1-6-3-7-2-4/h1-3H

Upstream product

• 22536-67-0 2,5-dichloropyrimidine 
• 288-32-4 1H-imidazole 
• 67-66-3 chloroform 
• 766-40-5 Mucochloric acid 
• 77287-34-4 formamide 
• 616-47-7 1-methyl-1H-imidazole 
• 18156-74-6 1-(Trimethylsilyl)imidazole 
• 24903-95-5 nopinone 

Downstream Products

• 63558-71-4 5-(furan-2-yl)pyrimidine 
• 69491-47-0 5-(4-methoxyphenyl)pyrimidine 
• 1033752-75-8 N-benzyl-N-methylpyrimidin-5-amine 
• 1609735-17-2 5-chloro-4-(2-(phenylsulfonyl)propan-2-yl)pyrimidine 
• 40805-79-6 pyrimidine-5-carbonitrile 
• 865761-52-0 N-(5-pyrimidinyl)-N-methylphenylamine 
• 64224-64-2 5-chloro-4-ethoxycarbonylpyrimidine 
• 18213-90-6 2-phenoxypyrimidine 
• 34771-45-4 5-phenylpyrimidine 
• 114969-48-1 5-chloropyrimidine N-oxide 
• 130532-92-2 5-chloro-3-phenyl-pyridin-2-ylamine 
• 130532-93-3 (5-Chloro-pyrimidin-4-yl)-phenyl-acetonitrile 

Relevant articles and documents

Bridged Hydroquinolines

The pyridannulation procedure of condensing vinamidinium salts with ketones having a free α-methylene has been adapted to prepare 3-substituted 5,6,7,8-tetrahydroquinolines; characterization data for the seven systems synthesized are reported.Conditions required are less drastic than those for recently reported alternative approaches to analogous systems.The adaption has considerable generality even though 5,8-methano-bridged 5,6,7,8-tetrahydroquinolines are not accessible through it.Chirality in the starting ketone, not affected by exposure to enolizing conditions, is preserved in the pyridannulated products.

Process for preparing 5-halopyrimidines

The reaction of formamide at high temperature with a 4-halo-5-hydroxy-2(5H)-furanone provides high yields of 5-chloro or 5-bromopyrimidines.

Reactions of Halogenomethanes in the Vapor Phase. Part 4. The Reactions of Imidazoles with Chloroform at 550 deg C, and a Comparison with their Liquid-phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

1-Unsubstituted imidazoles and chloroform at 550 deg C in a flow system give mainly 5-chloropyrimidines, together with 4-chloropyrimidines and chloropyrazines.The effects of methyl substituents on the ratio of products is considered.The liquid-phase reactions of 2-methyl- and 2,4,5-trimethyl-imidazole under conditions in which dichlorocarbene is said to be formed in basic or neutral conditions were studied, and compared with the gas-phase reactions with chloroform.