1729-38-0Relevant articles and documents
An expeditious synthesis of lasofoxifene and nafoxidine via the novel three-component coupling reaction
Sano, Yoshiyuki,Nakata, Kenya,Otoyama, Takafumi,Umeda, Sei,Shiina, Isamu
, p. 40 - 41 (2007)
The simple and efficient synthesis of lasofoxifene (4), a possible candidate for alleviating osteoporosis, via the novel three-component coupling reaction among 4-pivaloyloxybenzaldehyde (5), cinnamyltrimethylsilane (6), and anisole in the presence of HfCl4 is illustrated. The successive cationic cyclization of the coupling product, olefin formation, and migration of the double-bond are performed to afford the common synthetic intermediate of lasofoxifene (4) and nafoxidine (3) via a very concise procedure. Copyright
NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF
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Page/Page column 18-19, (2010/06/17)
Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome i
PROCESS FOR PRODUCTION OF LASOFOXIFENE OR ANALOGUE THEREOF
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Page/Page column 19-20; 30, (2008/12/04)
Disclosed is a novel process for production of lasofoxifene, nafoxidine or an analogue thereof, which comprises reduced number of reaction steps, has a high efficiency, and is practically advantageous. For the production of lasofoxifene or an analogue the