1769-84-2

Basic information

• Product Name: 6-methoxy-2-phenyl-tetralone
• Synonyms: 6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1(2H)-one;6-Methoxy-2-phenyltetralone;6-Methoxy-2-phenyl-1-tetralone;6-Methoxy-2-phenylnaphthalen-1(4H)-one;3,4-dihydro-6-methoxy-2-phenyl-1(2H)-Naphthalenone;6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1(2H)
• CAS NO: 1769-84-2
• Molecular Formula: C₁₇H₁₆O₂
• Molecular Weight: 252.31
• Mol File: 1769-84-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 113-116 °C
• Boiling Point: 429.897 °C at 760 mmHg
• Flash Point: 198.152 °C
• Appearance: /
• Density: 1.142 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-methoxy-2-phenyl-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-2-phenyl-tetralone(1769-84-2)
• EPA Substance Registry System: 6-methoxy-2-phenyl-tetralone(1769-84-2)

Safety Data

• Hazardous Substances Data: 1769-84-2(Hazardous Substances Data)

Usage

General Description

6-methoxy-2-phenyl-tetralone is a chemical compound with the molecular formula C16H16O2. It is a tetralone derivative with a methoxy group at the 6-position and a phenyl group at the 2-position. 6-methoxy-2-phenyl-tetralone is a member of the tetralone family, which has various biological activities. It is a potential candidate for pharmaceutical research due to its structural properties and potential pharmacological effects. Research on 6-methoxy-2-phenyl-tetralone is focused on its potential therapeutic applications, including its anti-inflammatory, analgesic, and neuroprotective properties. Additionally, it has been studied for its potential use in the treatment of neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease.

InChI:InChI=1/C17H16O2/c1-19-14-8-10-16-13(11-14)7-9-15(17(16)18)12-5-3-2-4-6-12/h2-6,8,10-11,15H,7,9H2,1H3

Upstream product

• 108-90-7 chlorobenzene 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 108-86-1 bromobenzene 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 100-52-7 benzaldehyde 
• 1729-33-5 2-Phenyl-4-(3-methoxyphenyl)-4-ketobutyronitril 
• 22966-24-1 1-(3-methoxyphenyl)-3-phenyl-2-propene-1-one 
• 140-29-4 phenylacetonitrile 
• 5020-40-6 4-(m-Methoxyphenyl)-2-phenylbutyronitril 
• 1729-35-7 4-(3-methoxyphenyl)-2-phenylbutyric acid 
• 2146-61-4 3-methoxyphenethyl bromide 
• 325723-04-4 Phenylbiphenyl-2,2'-ylenebismuth diacetate 
• 20933-24-8 2-bromo-6-methoxy-1-tetralone 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 14088-05-2 2-Phenyl-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol 
• 1729-38-0 1-(p-hydroxyphenyl)-6-methoxy-2-phenyl-3,4-dihydronaphthalene 
• 28717-78-4 7-methoxy-3-phenyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 111026-89-2 6-Methoxy-2-phenyl-3,4-dihydro-2H-naphthalen-1-one oxime 
• 1908-03-8 6-Methoxy-1-<4-(2-diaethylamino-aethoxy)-phenyl>-2-phenyl-3,4-dihydro-naphthalin 
• 4897-62-5 1-(4-Dimethylamino-phenyl)-2-phenyl-6-methoxy-3,4-dihydro-naphthalin 
• 4256-35-3 6-Methoxy-1,2-diphenyl-1,2,3,4-tetrahydro-naphthalen-1-ol 
• 1729-39-1 6-hydroxy-2-phenyl-3,4-dihydro-2H-naphthalen-1-one 
• 4310-62-7 1-(4-Fluoro-phenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol 
• 4310-63-8 4-(4-Fluoro-phenyl)-7-methoxy-3-phenyl-1,2-dihydro-naphthalene 
• 4310-64-9 1-[p-(2,3-Dihydroxypropoxy)phenyl]-2-phenyl-6-methoxy-3,4-dihydronaphthalin 
• 4256-41-1 2-[p-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]-2-methylpropionsaeure 
• 4256-40-0 Ethyl 2-[p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]-2-methylpropionat 
• 5879-91-4 4-(cis-6-methoxy-2-phenyltetralin-1-yl)phenol 

Relevant articles and documents

Development of concise two-step catalytic approach towards lasofoxifene precursor nafoxidine

We have elaborated a two-step catalytic approach to nafoxidine, a key precursor to lasofoxifene. Firstly, an efficient α-arylation of 6-methoxy-3,4-dihydronaphthalen-1(2H)-one with chlorobenzene was developed, which operates at low 0.1 mol% Pd-132 catalyst loading in the presence of 1.9 equivalents of sodium tert-butoxide at 60 °C in 1,4-dioxane and provides 6-methoxy-2-phenyl-3,4-dihydronaphthalen-1(2H)-one in 90% yield. Secondly, we have demonstrated that 6-methoxy-2-phenyl-3,4-dihydronaphthalen-1(2H)-one can be converted to nafoxidine in 61% yield via CeCl3 promoted reaction with (4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)lithium, which is formed in-situ from the corresponding arylbromide precursor and n-butyllithium. Altogether, the shortest two-step approach to nafoxidine from simple tetralone commodity starting material has been developed with overall 55% yield. The developed synthetic approach to nafoxidine has several beneficial aspects over the one used in the synthetic route primarily developed for the preparation of lasofoxifene.

ESTROGEN RECEPTOR-MODULATING COMPOUNDS

Described herein are compounds that are estrogen receptor modulators of formula I' Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

N-heterocyclic carbene-palladium(II)-1-methylimidazole complex catalyzed α-arylation reactions of tetralones with aryl chlorides and further transformation of the products

NHC-Pd(II)-Im complex 1 has proven to be an efficient catalyst in the reaction between tetralones 2 and aryl chlorides 3, giving the α-arylated tetralones 4 in good to high yields. In addition, if the above reaction mixture was exposed to air at room temp