17428-96-5Relevant articles and documents
Development of a Modified Bouveault-Blanc Reduction for the Selective Synthesis of α,α-Dideuterio Alcohols
Han, Minhui,Ma, Xiaodong,Yao, Shangchu,Ding, Yuxuan,Yan, Zihan,Adijiang, Adila,Wu, Yufei,Li, Hengzhao,Zhang, Yuntong,Lei, Peng,Ling, Yun,An, Jie
, p. 1285 - 1290 (2017)
A modified Bouveault-Blanc reduction has been developed for the synthesis of α,α-dideuterio alcohols from carboxylic acid esters. Sodium dispersions are used as the electron donor in this electron transfer reaction, and ethanol-d1 is employed a
The invention relates to an acyl fluoride compound reduction and deuteration synthesis α, α - dideuterium alcohol. Method for deuterated drugs
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Paragraph 0038-0041, (2021/08/25)
The invention relates to an α, α - dideuterium-substituted alcohol compound and a reduction deuteration method for preparing an acyl fluoride compound of α, α - dideuterium-substituted alcohol compounds, characterized in that α, α - dideuterium-substituted alcohol compounds represented by the general formula 2 (1) are reacted in an organic solvent I by a deuterium donor reagent. The method solves the problems that in the prior art α, α - dideuterium-substituted alcohol compounds are prepared by using inflammable reductant, poor selectivity and atomic economy, the invention establishes a method for reducing and deuteration of acyl fluoride compounds based on single electron transfer reduction deuteration reaction. The method can be used for preparing α, α - dideuterium-substituted alcohol compounds, and has the advantages of high product deuterium substitution rate, good regioselectivity, good chemical selectivity, low reagent price, simple operation, mild conditions and wide substrate application range.
A trinuclear chromium(iii) chlorocarbyne
Kurogi, Takashi,Irifune, Keiichi,Enoki, Takahiro,Takai, Kazuhiko
, p. 5199 - 5202 (2021/05/31)
Reduction of CCl4 by CrCl2 in THF afforded a trinuclear chromium(iii) carbyne [CrCl(thf)2]3(μ3-CCl)(μ-Cl)3. The chlorocarbyne complex reacted with aldehydes to afford chloroallylic alcohols and terminal alkynes. The mechanistic study proposed two competitive pathways via an α-chlorovinyl intermediate.
