30911-16-1

Basic information

• Product Name: Benzenepropanethioic acid, S-ethyl ester
• CAS NO: 30911-16-1
• Molecular Formula: C11H14OS
• Molecular Weight: 194.298
• Mol File: 30911-16-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenepropanethioic acid, S-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanethioic acid, S-ethyl ester(30911-16-1)
• EPA Substance Registry System: Benzenepropanethioic acid, S-ethyl ester(30911-16-1)

Safety Data

• Hazardous Substances Data: 30911-16-1(Hazardous Substances Data)

Upstream product

• 4250-02-6 1-diazo-3-phenyl-2-propanone 
• 75-08-1 ethanethiol 
• 108387-99-1 (E)-3-phenyl-thioprop-2-ene-oic acid (S)-ethyl ester 
• 104-55-2 3-phenyl-propenal 
• 621-82-9 Cinnamic acid 
• 42893-53-8 S-ethyl thiocinnamate 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 
• 811-51-8 sodium thioethylate 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 726-26-1 phenyl 3-phenylpropanoate 
• 501-52-0 3-Phenylpropionic acid 
• 122-97-4 3-Phenyl-1-propanol 
• 17428-96-5 1,1-d2-3-phenylpropan-1-ol 
• 5739-38-8 1-(4-methoxyphenyl)-3-phenylpropan-1-one 
• 1083-30-3 dihydrochalcone 
• 94756-67-9 1-Phenyl-4-benzyliden-heptanon-⁽³⁾ 
• 93877-06-6 2-Methyl-1,5-diphenyl-penten-⁽¹⁾-on-⁽³⁾ 
• 20795-51-1 1-phenylpentan-3-one 
• 15814-45-6 allyl 3-phenylpropionate 
• 130260-32-1 3-Phenyl-propionic acid (1S,2S)-2-bromo-cyclooctyl ester 

Relevant articles and documents

Metal-Free Hydropyridylation of Thioester-Activated Alkenes via Electroreductive Radical Coupling

An electrochemical hydropyridylation of thioester-activated alkenes with 4-cyanopyridines has been developed. The reactions experience a tandem electroreduction of both substrates on the cathode surface, protonation, and radical cross-coupling process, resulting in a variety of valuable pyridine variants, which contain a tertiary and even a quaternary carbon at the α-position of pyridines, in high yields. The employment of thioesters to the conjugated alkenes enables no requirement of catalyst and high temperature, representing a highly sustainable synthetic method.

Nickel-Catalyzed Coupling of Arylzinc Halides with Thioesters

The Pd-catalyzed Fukuyama reaction of thioesters with organozinc reagents is a mild, functional-group-tolerant method for acylation chemistry. Its Ni-catalyzed variant might be a sustainable alternative to expensive catalytic Pd sources. We investigated the reaction of S-ethyl thioesters with aryl zinc halides with hetero- and homotopic Ni precatalysts and several ligands. The results show that both homo- and heterotopic species may contribute to catalysis. The substrate scope using an operationally homogeneous defined Ni complex was established. Acyl radicals are postulated as short-lived intermediates.

Conjugate reduction and reductive aldol cyclization of α,β- unsaturated thioesters catalyzed by (BDP)CuH

A conjugate reduction of α,β-unsaturated thioesters catalyzed by copper hydride using PMHS as stoichiometric reductant has been developed. 1,2-Bis(diphenylphosphino)benzene (BDP) was the most effective ligand for this reduction. Saturated thioesters could be produced in excellent yields when the substituent on the thiol is not sterically-demanding. This protocol was applied to induce the reductive aldol cyclization of keto-enethioates, which could offer β-hydroxythioesters in moderate to good yields.