174635-69-9 Usage
Description
SB 222200, also known as 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide, is a chemical agent derived from acylpiperazinyl-pyrazoles. It is primarily recognized for its antagonistic properties against the NK3 receptor, making it a promising candidate in the development of antipsychotic medications.
Uses
Used in Pharmaceutical Industry:
SB 222200 is used as an antagonist for the NK3 receptor, which plays a significant role in various physiological processes. Its application in this industry is primarily for the development of antipsychotic medications, targeting the treatment of psychiatric disorders.
Used in Research and Development:
In the field of research and development, SB 222200 serves as a valuable tool for studying the functions and interactions of the NK3 receptor. This understanding can lead to the discovery of new therapeutic approaches and the development of novel antipsychotic drugs.
Used in Preparation of Acylpiperazinyl-Pyrazoles:
SB 222200 is also used in the preparation of acylpiperazinyl-pyrazoles, a class of compounds with potential applications in the treatment of various psychiatric conditions. The development of these compounds can contribute to the advancement of antipsychotic medications and improve patient outcomes.
Biological Activity
Potent and selective non-peptide NK 3 receptor antagonist. K i values are 4.4, >100,000 and 250 nM for human NK 3 , NK 1 and NK 2 receptors respectively. Brain penetrant and active in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 174635-69-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,6,3 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 174635-69:
(8*1)+(7*7)+(6*4)+(5*6)+(4*3)+(3*5)+(2*6)+(1*9)=159
159 % 10 = 9
So 174635-69-9 is a valid CAS Registry Number.
InChI:InChI=1/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1
174635-69-9Relevant articles and documents
Functionalization through lithiation of (S)-N-(1-phenylpropyl)-2- phenylquinoline-4-carboxamide. Application to the labeling with carbon-11 of NK-3 receptor antagonist SB 222200
Bennacef, Idriss,Perrio, Cecile,Lasne, Marie-Claire,Barre, Louisa
, p. 2161 - 2165 (2007/10/03)
Lithiation of (S)-N-(1-phenylpropyl)-2-phenylquinoline-4-carboxamide with the complex n-BuLi/TMEDA (1/1 molar ratio) in THF at -60 °C for 5 h occurred selectively at the position 3 of the quinoline ring. This selectivity was shown by the absence of racemi
2-Phenyl-4-quinolinecarboxamides: A novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor
Giardina,Sarau,Farina,Medhurst,Grugni,Foley,Raveglia,Schmidt,Rigolio,Vassallo,Vecchietti,Hay
, p. 2281 - 2284 (2007/10/03)
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