17483-54-4

Basic information

• Product Name: 2,4,6-trimethoxybenzamide
• Synonyms: 2,4,6-trimethoxybenzamide
• CAS NO: 17483-54-4
• Molecular Weight: 211.218
• Mol File: 17483-54-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4,6-trimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-trimethoxybenzamide(17483-54-4)
• EPA Substance Registry System: 2,4,6-trimethoxybenzamide(17483-54-4)

Safety Data

• Hazardous Substances Data: 17483-54-4(Hazardous Substances Data)

Upstream product

• 570-02-5 2,4,6-trimethoxybenzoic acid 
• 621-23-8 1,2,3-trimethoxybenzene 
• 17483-30-6 2,4,6-Trimethoxy-N-chlorsulfonyl-benzamid 

Downstream Products

• 102438-99-3 2,4,6-trimethoxyaniline hydrochloride 
• 14227-17-9 2,4,6-trimethoxyaniline 

Relevant articles and documents

Phloroglucinol derivatives as anti-tumor agents: synthesis, biological activity evaluation and molecular docking studies

Phloroglucinol compounds isolated from Dryopteris fragrans (L.) Schott showed a variety of biological activities, such as anticancer and anti-inflammatory. In this study, we have made a number of modifications around the scaffold of phloroglucinol and synthesized phloroglucinol derivatives A1–A9, B1–B9, and C1–C3. We synthesized these compounds and investigated their effect on four human cancer cell lines (A-549, MCF-7, Hela, HepG2 cell lines) via MTT assay in vitro. The results revealed that all compounds exhibited certain antiproliferative activities on cancer cell lines and excellent inhibitory effects on MCF-7, in which compound C2 was the best with the IC50 value of 18.49 μM, exceeding that of 5-fluorouracil. Moreover, the cell apoptosis test showed that compound C2 induced apoptosis in a concentration-dependent manner. Furthermore, the results of molecular docking analysis explained the probable interaction between the active compounds and active sites of target protein 4I22 and 1OG5. [Figure not available: see fulltext.]