175153-03-4

Basic information

• Product Name: 4-(2-OXO-PIPERIDIN-1-YL)-BENZOIC ACID
• Synonyms: 4-(2-OXO-PIPERIDIN-1-YL)-BENZOIC ACID;Benzoic acid,4-(2-oxo-1-piperidinyl)-
• CAS NO: 175153-03-4
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol File: 175153-03-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 508.3 °C at 760 mmHg
• Flash Point: 261.2 °C
• Appearance: /
• Density: 1.284 g/cm³
• CAS DataBase Reference: 4-(2-OXO-PIPERIDIN-1-YL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-OXO-PIPERIDIN-1-YL)-BENZOIC ACID(175153-03-4)
• EPA Substance Registry System: 4-(2-OXO-PIPERIDIN-1-YL)-BENZOIC ACID(175153-03-4)

Safety Data

• Hazardous Substances Data: 175153-03-4(Hazardous Substances Data)

Usage

General Description

4-(2-oxo-piperidin-1-yl)-benzoic acid is a chemical compound with the molecular formula C15H15NO3. It is a white to off-white powder and is used in pharmaceutical research and development. 4-(2-OXO-PIPERIDIN-1-YL)-BENZOIC ACID is an organic acid that contains a piperidine ring and a benzoic acid group. It has potential applications in drug discovery and medicinal chemistry, particularly in the development of new therapeutic agents. The compound may also have biological activity and could be used as a building block for the synthesis of other complex molecules. Its precise properties and uses are still being explored by researchers in the field.

Upstream product

• 503614-97-9 methyl 4-(2-oxopiperidin-1-yl)benzoate 
• 675-20-7 piperidin-2-one 
• 619-44-3 methyl 4-iodobenzoate 
• 889129-50-4 4-(5-chloro-pentanoylamino)-benzoic acid methyl ester 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 619-45-4 4-methoxycarbonyl aniline 
• 444815-14-9 N-(4-ethoxycarbonylphenyl)-2-piperidone 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Downstream Products

• 503613-37-4 5-chloro-N-(5-chloropyridin-2-yl)-2-({4-[(2-oxopiperidine)-1-yl]benzoyl}amino)benzamide 
• 197446-35-8 (R)-N-[8-(4-Methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-(4-piperidon 1-yl)benzamide 
• 503613-45-4 5-chloro-N-(5-chloropyridin-2-yl)-3-methoxy-2-[4-(2-oxopiperidin-1-yl)benzoylamino]benzamide 
• 1394169-65-3 (S)-N-(4-chlorophenyl)-2-(4-(2-oxopiperidin-1-yl)benzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 678179-39-0 3-[4-(2-oxo-piperidin-1-yl)-benzoylamino]-propionic acid methyl ester 
• 221360-86-7 4-(5-oxo-1,4-diazepan-1-yl)benzoic acid 

Relevant articles and documents

Ring size changes in the development of class I HDAC inhibitors

Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.

LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS

The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties

Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit a