197446-35-8

Basic information

• Product Name: (R)-N-[8-(4-Methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-(4-piperidon 1-yl)benzamide
• Synonyms: (R)-N-[8-(4-Methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-(4-piperidon 1-yl)benzamide
• CAS NO: 197446-35-8
• Molecular Weight: 446.593
• Mol File: 197446-35-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N-[8-(4-Methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-(4-piperidon 1-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-[8-(4-Methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-(4-piperidon 1-yl)benzamide(197446-35-8)
• EPA Substance Registry System: (R)-N-[8-(4-Methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-(4-piperidon 1-yl)benzamide(197446-35-8)

Safety Data

• Hazardous Substances Data: 197446-35-8(Hazardous Substances Data)

Upstream product

• 197445-18-4 (R)-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-amine 
• 543-27-1 isobutyl chloroformate 
• 175153-03-4 4-[(2-oxo-piperidine)-1-yl]benzoic acid 

Relevant articles and documents

Substituted 1,2,3,4-tetrahydronaphthalene derivatives

PCT No. PCT/SE97/00469 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Mar. 20, 1997 PCT Pub. No. WO97/34883 PCT Pub. Date Sep. 25, 1997New piperidinyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formula wherein X is N or CH; Y is NR2CH2, CH2-NR2, NR2-CO, CO-NR2 or NR2SO2; R1is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, where aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted; n is 0-4; as (R)-enantiomer, (S)-enantiomer or a racemate in the form of the free base or a pharmaceutically acceptable salt or hydrate thereof; a pharmaceutical formulation containing the compounds, use of the compounds in the treatment of 5-hydroxytryptamine mediated disorders, processes for the preparation of the compounds and intermediates for the preparation of the compounds.