17556-41-1

Basic information

• Product Name: 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol
• CAS NO: 17556-41-1
• Molecular Weight: 194.129
• Mol File: 17556-41-1.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol(17556-41-1)
• EPA Substance Registry System: 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol(17556-41-1)

Safety Data

• Hazardous Substances Data: 17556-41-1(Hazardous Substances Data)

Upstream product

• 2648079-79-0 S-(trifluoromethyl)thianthrenium triflate 
• 459-57-4 4-fluorobenzaldehyde 
• 807329-97-1 TurboGrignard 
• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 66286-21-3 2',3',4',5'-tetrafluoroacetophenone 
• 655-32-3 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone 
• 112022-81-8 (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole 
• 2314-97-8 iodotrifluoromethane 
• 383-63-1 ethyl trifluoroacetate, 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 75-63-8 Bromotrifluoromethane 

Downstream Products

• 848926-12-5 (R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol 
• 890085-08-2 (S)-4-fluoro-α,α,α-(trifluoromethyl)-benzenemethanol 
• 1135311-90-8 (S)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethyl isobutyrate 
• 1135312-25-2 2,2,2-trifluoro-1-(4'-fluorophenyl)ethyl isobutyrate 
• 81577-13-1 1-(1-Chloro-2,2,2-trifluoro-ethyl)-4-fluoro-benzene 
• 655-32-3 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone 
• 1226502-59-5 2-chloro-N-{3-[2,2,2-trifluoro-1-(4-fluorophenyl)ethoxy]-quinoxalin-2-yl}benzenesulfonamide 
• 50561-99-4 1-fluoro-4-(2,2,2-trifluoroethyl)benzene 
• 50562-20-4 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-(4-fluoro-phenyl)-ethyl ester 

Relevant articles and documents

Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction

A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared. The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction, affording the products bearing a trifluoromethylated all-carbon quaternary stereocenter with moderate to excellent yields (up to 99%) and good to excellent enantioselectivies (up to > 99.9% ee). Moreover, a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.

Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF3+, CF3?, and CF3-Reactivity

Here we report the synthesis and application of trifluoromethyl thianthrenium triflate (TT-CF3+OTf-) as a novel trifluoromethylating reagent, which is conveniently accessible in a single step from thianthrene and triflic anhydride. We demonstrate the use of TT-CF3+OTf- in electrophilic, radical, and nucleophilic trifluoromethylation reactions.

Synthesis of Unsymmetric Triarylmethanes Bearing CF 3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of δ-Trifluo romethyl Substituted para -Quinone Methides

Pre-synthesized δ-CF 3-δ-aryl-disubstituted para -quinone methides bearing δ-substituents were identified as isolable and storable substrates for 1,6-arylation reactions. A broad range of electron-rich arenes and heteroarenes participated in the arylation process, furnishing a wide array of unsymmetrical CF 3-substituted triarylmethanes in high efficiency. The mild and expeditious protocol exhibited broad scopes of both arene and para -quinone methide components.