175613-38-4 Usage
Description
9-HydroxyMethyl-10-hydroxy CaMptothecin, a metabolite of Camptothecin, is a potent topoisomerase inhibitor with significant potential in cancer therapy. It possesses unique chemical properties that enable it to interact with DNA and inhibit the activity of topoisomerase enzymes, which are essential for DNA replication. This interaction leads to the prevention of cancer cell proliferation and the eventual death of cancer cells.
Uses
Used in Pharmaceutical Industry:
9-HydroxyMethyl-10-hydroxy CaMptothecin is used as an anticancer agent for its ability to inhibit topoisomerase enzymes, which play a crucial role in DNA replication. By targeting these enzymes, it disrupts the replication process in cancer cells, leading to their death and potentially offering a treatment option for various types of cancer.
Used in Cancer Research:
In the field of cancer research, 9-HydroxyMethyl-10-hydroxy CaMptothecin serves as a valuable compound for studying the mechanisms of topoisomerase inhibition and its effects on cancer cell proliferation. This research can contribute to the development of novel cancer therapies and a better understanding of the molecular basis of cancer.
Used in Drug Development:
9-HydroxyMethyl-10-hydroxy CaMptothecin is utilized in the development of new cancer drugs, as its topoisomerase inhibitory properties make it a promising candidate for the creation of more effective and targeted cancer treatments. Researchers can use this compound as a starting point for designing new drugs that can potentially overcome resistance and improve patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 175613-38-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,6,1 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 175613-38:
(8*1)+(7*7)+(6*5)+(5*6)+(4*1)+(3*3)+(2*3)+(1*8)=144
144 % 10 = 4
So 175613-38-4 is a valid CAS Registry Number.
175613-38-4Relevant articles and documents
Topotecan dynamics, tautomerism and reactivity - 1H/ 13C NMR and ESI MS study
Hyz, Karolina,Kawecki, Robert,Bednarek, Elzbieta,Bocian, Wojciech,Sitkowski, Jerzy,Kozerskia, Lech
experimental part, p. 575 - 584 (2011/05/05)
Topotecan (TPT) is in clinical use as an antitumor agent, hycamtin. Because of this, it requires both biologically and chemically useful information to be available. TPT acts by binding to the covalent complex formed by nicked DNA and topoisomerase I. This has a poisonous effect since inserted into the single-strand nick and TPT inhibits its religation. We used NMR to trace TPT dynamics, tautomerism and solvolysis products in various solvents and conditions. Chemical stability was assessed in methanol and DMSO as compared to water, and the regioselectivity of the N- and O-methylation was studied using various alkylating agents. The reaction products of quaternization of the nitrogen atom and methylation of the oxygen atom were characterized by means of ESI MS, 1H/13C-HMBC and -HSQCAD NMR. We have focused on the NMR characterization of TPT with an anticipation that its aggregation, tumbling properties and the intramolecular dipolar interactions will be a common feature for other compounds described in this article. These features can also be useful in tracing the interactions of this class of topoisomerase I (TopoI) poisons with DNA. Moreover, the results explained shed light on the recently disclosed problem of lack of stability of TPT in the heart tissue homogenate samples using the analytical assays developed for this class of compounds carried out in the presence ofmethanol. Copyright
