1766-28-5

Basic information

• Product Name: 1-(4-Fluorophenyl)-2-Methylpropan-1-ol
• Synonyms: 1-(4-Fluorophenyl)-2-Methylpropan-1-ol
• CAS NO: 1766-28-5
• Molecular Weight: 168.211
• Mol File: 1766-28-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(4-Fluorophenyl)-2-Methylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)-2-Methylpropan-1-ol(1766-28-5)
• EPA Substance Registry System: 1-(4-Fluorophenyl)-2-Methylpropan-1-ol(1766-28-5)

Safety Data

• Hazardous Substances Data: 1766-28-5(Hazardous Substances Data)

Usage

Classification

Primary alcohol

Physical state

Colorless liquid

Odor

Slightly sweet and floral

Uses

a. Synthesis of pharmaceuticals
b. Synthesis of other organic compounds
c. Building block for various chemicals
d. Chiral auxiliary in asymmetric synthesis
e. Potential intermediate in the manufacture of agrochemicals and fragrances

Upstream product

• 67-56-1 methanol 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 459-57-4 4-fluorobenzaldehyde 
• 75-26-3 isopropyl bromide 
• 78-84-2 isobutyraldehyde 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 75-30-9 2-iodo-propane 
• 920-39-8 isopropylmagnesium bromide 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 26393-91-9 1-(4-fluorophenyl)-2-methylpropan-1-one 
• 335287-91-7 1-(4-fluorophenyl)-2-hydroxy-2-methylpropan-1-one 
• 36758-12-0 2-methyl-1-(4-phenoxyphenyl)propan-1-one 
• 702-09-0 1-fluoro-4-(2-methylprop-1-en-1-yl)benzene 

Relevant articles and documents

Manganese(I)-Catalyzed β-Methylation of Alcohols Using Methanol as C1 Source

Highly selective β-methylation of alcohols was achieved using an earth-abundant first row transition metal in the air stable molecular manganese complex [Mn(CO)2Br[HN(C2H4PiPr2)2]] 1 ([HN(C2H4PiPr2)2]=MACHO-iPr). The reaction requires only low loadings of 1 (0.5 mol %), methanolate as base and MeOH as methylation reagent as well as solvent. Various alcohols were β-methylated with very good selectivity (>99 %) and excellent yield (up to 94 %). Biomass derived aliphatic alcohols and diols were also selectively methylated on the β-position, opening a pathway to “biohybrid” molecules constructed entirely from non-fossil carbon. Mechanistic studies indicate that the reaction proceeds through a borrowing hydrogen pathway involving metal–ligand cooperation at the Mn-pincer complex. This transformation provides a convenient, economical, and environmentally benign pathway for the selective C?C bond formation with potential applications for the preparation of advanced biofuels, fine chemicals, and biologically active molecules.

Halogen-bonded iodonium ion catalysis: A route to α-hydroxy ketones: Via domino oxidations of secondary alcohols and aliphatic C-H bonds with high selectivity and control

A domino synthesis of α-hydroxy ketones has been developed from benzylic secondary alcohols employing catalytic iodonium ions stabilized by DMSO. The reaction proceeds through an unprecedented sequential oxidation of alcohols to ketone and its α-hydroxylation in a controlled manner. The spectroscopic evidence establishes the possibility of formation of a stable halogen-bonded adduct between DMSO and iodonium ions.

ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP

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